Evidence map›Paper›PMID 39269684›Full record

ArticleThe Journal of physiology2025

Protein kinase C epsilon contributes to chronic mechanoreflex sensitization in rats with heart failure.

Alec L E Butenas, Shannon K Parr, Joseph S Flax, Raimi J Carroll, Ashley M Baranczuk, Carl J Ade, K Sue Hageman, Timothy I Musch, Steven W Copp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alec L E ButenasDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.ORCID 0000-0002-2452-5018
Shannon K ParrDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.ORCID 0000-0002-0393-7312
Joseph S FlaxDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Raimi J CarrollDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Ashley M BaranczukDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Carl J AdeDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.ORCID 0000-0002-1837-2342
K Sue HagemanDepartment of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.
Timothy I MuschDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Steven W CoppDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.

Funding

Signaling pathways regulating mechanoreflex sensitization in cardiovascular diseaseR01HL161160 · NHLBI · KANSAS STATE UNIVERSITY · PI COPP, STEVEN W · 2022 to 2025
$2.1M
Exercise Pressor Reflex Dysfunction in Heart Failure: Mechanisms and TreatmentR01HL142877 · NHLBI · KANSAS STATE UNIVERSITY · PI COPP, STEVEN W · 2018 to 2021
$1.2M
NHLBI NIH HHS R01 HL142877NHLBI NIH HHS R01 HL161160
6 · The paper itself

Abstract

We investigated second-messenger signalling components linked to the stimulation of G

Indexed as

Heart FailureProtein Kinase C-epsilonAnimalsHindlimbIntercellular Signaling Peptides and ProteinsKidneyMaleMuscle, SkeletalRatsRats, Sprague-DawleyReflexSpider VenomsSympathetic Nervous SystemIntercellular Signaling Peptides and ProteinsMTx4 protein, Grammostola spatulataProtein Kinase C-epsilonSpider Venomsexercise pressor reflexheart failure reduced ejection fractionIP3muscle afferents

Identifiers

PMID39269684
PMCPMC11903370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.