Evidence map›Paper›PMID 39269678›Full record

ReviewMolecular and cellular biochemistry2025

SIRT1 in acute lung injury: unraveling its pleiotropic functions and therapeutic development prospects.

Yina Chen, Shuangyan Peng, Junjie Liang, Ke Wei

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yina Chen *Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China.
Shuangyan Peng *Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China.
Junjie Liang *Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China.
Ke WeiMedical School, Hunan University of Chinese Medicine, Changsha, 410208, China. 004343@hnucm.edu.cn.

Funding

Project of Hunan Provincial Health Commission D202301067791the project of Changsha Outstanding Innovative Youth Training program 2307003
6 · The paper itself

Abstract

Acute lung injury (ALI) is a continuum of lung changes caused by multiple lung injuries, often associated with severe complications and even death. In ALI, macrophages, alveolar epithelial cells and vascular endothelial cells in the lung are damaged to varying degrees and their function is impaired. Research in recent years has focused on the use of SIRT1 for the treatment of ALI. In this paper, we reviewed the role of SIRT1 in ALI in terms of its cellular and molecular mechanism, targeting of SIRT1 by non-coding RNAs and drug components, as well as pointing out the value of SIRT1 for clinical diagnosis and prognosis. Based on the current literature, SIRT1 exhibits diverse functionalities and possesses significant therapeutic potential. Targeting SIRT1 may provide new therapeutic ideas for the treatment of ALI.

Indexed as

Acute Lung InjurySirtuin 1AnimalsHumansSIRT1 protein, humanSirtuin 1Acute lung injuryNLRP3 inflammasomeNon-coding RNAsPolarizationSirt1

Identifiers

PMID39269678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.