Evidence map›Paper›PMID 39269656›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Comparison of PSMA immunohistochemistry scoring systems to parametric [

Niloefar Ahmadi Bidakhvidi, Thomas Gevaert, Maxim De Schepper, Marcella Baldewijns, Enrique Havinga, Wies Deckers, Annouschka Laenen, Gaëtan Devos, Alexander Giesen, Steven Joniau and 4 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Relationship between [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  2. Article
  3. The value of [Quantitative imaging in medicine and surgery · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Niloefar Ahmadi BidakhvidiNuclear Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-2225-0161
Thomas GevaertUrogenital, Abdominal and Plastic Surgery, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0001-6880-7183
Maxim De SchepperPathology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0001-9829-8535
Marcella BaldewijnsPathology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-0882-2944
Enrique HavingaRadiology, University Hospitals Leuven, Leuven, Belgium.
Wies DeckersNuclear Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-0907-7384
Annouschka LaenenInteruniversity Institute for Biostatistics and Statistical Bioinformatics, Leuven, Belgium.ORCID 0000-0002-1371-442X
Gaëtan DevosUrogenital, Abdominal and Plastic Surgery, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0002-6772-915X
Alexander GiesenUrogenital, Abdominal and Plastic Surgery, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3345-4573
Steven JoniauUrogenital, Abdominal and Plastic Surgery, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0003-3195-9890
Michel KooleNuclear Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0001-5862-640X
Wouter EveraertsUrology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-3157-7115
Christophe M DerooseNuclear Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-6080-1577
Karolien GoffinNuclear Medicine, University Hospitals Leuven, Leuven, Belgium. karolien.goffin@uzleuven.be.ORCID 0000-0002-7453-0229

Funding

Agentschap voor Innovatie door Wetenschap en Technologie IWT.140193
6 · The paper itself

Abstract

purposeQuantification of PSMA expression via PSMA PET is well-established, however quantification of PSMA via immunohistochemistry (IHC) is not standardized. Our aim was to determine the most optimal PSMA IHC scoring system to quantify PSMA expression with PSMA PET as reference standard.

methodsPrimary intermediate- and high-risk prostate cancer patients received an [

resultsFifty tumors in 46 patients were analysed. H-score had the best correlation with SUV

conclusionH-score had the best correlation with PSMA PET quantification and an acceptable interreader agreement. Therefore, we deem H-score the most optimal PSMA IHC scoring system.

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IIImmunohistochemistryMagnetic Resonance ImagingMultimodal ImagingNiacinamideOligopeptidesPositron-Emission TomographyProstatic NeoplasmsAgedFluorine RadioisotopesHumansMaleMiddle AgedAntigens, SurfaceFluorine RadioisotopesFOLH1 protein, humanGlutamate Carboxypeptidase IINiacinamideOligopeptidesPSMA-1007Parametric PETPET/MRPrimary prostate cancerPSMA immunohistochemistryPSMA PET

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.