Evidence map›Paper›PMID 39269654›Full record

ArticleActa neurochirurgica2024

The impact of hypertension on clinical outcomes in moyamoya disease: a multicenter, propensity score-matched analysis.

Basel Musmar, Joanna M Roy, Hammam Abdalrazeq, Elias Atallah, Kareem El Naamani, Ching-Jen Chen, Roland Jabre, Hassan Saad, Jonathan A Grossberg, Adam A Dmytriw and 32 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Basel MusmarDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Joanna M RoyDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Hammam AbdalrazeqDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Elias AtallahDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Kareem El NaamaniDepartment of Neurosurgery, University of Arizona college of medicine, Tucson, Arizona, USA.
Ching-Jen ChenDepartment of Neurosurgery, The University of Texas Health Science Center, Houston, TX, USA.
Roland JabreDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Hassan SaadDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Jonathan A GrossbergDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Adam A DmytriwDepartment of Medical Imaging, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mirhojjat KhorasanizadehDepartment of Neurosurgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Christopher S OgilvyDepartment of Neurosurgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Ajith J ThomasDepartment of Neurological Surgery, Cooper University Health Care, Cooper Medical School of Rowan University, Camden, NJ, USA.
Andre MonteiroDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Adnan SiddiquiDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Gustavo M CortezLyerly Neurosurgery, Baptist Health System, Jacksonville, FL, USA.
Ricardo A HanelLyerly Neurosurgery, Baptist Health System, Jacksonville, FL, USA.
Guilherme PortoDepartment of Neurosurgery and Neuroendovascular Surgery, Medical University of South Carolina, Charleston, SC, USA.
Alejandro M SpiottaDepartment of Neurosurgery and Neuroendovascular Surgery, Medical University of South Carolina, Charleston, SC, USA.
Anthony J PiscopoDepartment of Neurosurgery, University of Iowa Hospital and Clinics, Iowa City, IA, USA.
David M HasanDepartment of Neurosurgery, Duke University, Durham, NC, USA.
Mohammad GhorbaniDepartment of Neurosurgery, Firoozgar Hospital, Tehran, Iran.
Joshua WeinbergDepartment of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Shahid M NimjeeDepartment of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kimon BekelisGood Samaritan Hospital Medical Center, Babylon, NY, USA.
Mohamed M SalemDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Jan-Karl BurkhardtDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Akli ZetchiDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Charles MatoukDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Brian M HowardDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Rosalind LaiNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rose DuNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rawad AbbasDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Georgios S SioutasDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Abdelaziz AmllayDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Alfredo MunozDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Nabeel A HerialDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Stavropoula I TjoumakarisDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Michael Reid GoochDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Robert H RosenwasserDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA.
Pascal JabbourDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, Pennsylvania, 19107, USA. pascal.jabbour@jefferson.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundMoyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive steno-occlusive changes in the internal carotid arteries, leading to an abnormal vascular network. Hypertension is prevalent among MMD patients, raising concerns about its impact on disease outcomes. This study aims to compare the clinical characteristics and outcomes of MMD patients with and without hypertension.

methodsWe conducted a multicenter, retrospective study involving 598 MMD patients who underwent surgical revascularization across 13 academic institutions in North America. Patients were categorized into hypertensive (n=292) and non-hypertensive (n=306) cohorts. Propensity score matching (PSM) was performed to adjust for baseline differences.

resultsThe mean age was higher in the hypertension group (46 years vs. 36.8 years, p < 0.001). Hypertensive patients had higher rates of diabetes mellitus (45.2% vs. 10.7%, p < 0.001) and smoking (48.8% vs. 27.1%, p < 0.001). Symptomatic stroke rates were higher in the hypertension group (16% vs. 7.1%; OR: 2.48; 95% CI: 1.39-4.40, p = 0.002) before matching. After PSM, there were no significant differences in symptomatic stroke rates (11.1% vs. 7.7%; OR: 1.5; CI: 0.64-3.47, p = 0.34), perioperative strokes (6.2% vs. 2.1%; OR 3.13; 95% CI: 0.83-11.82, p = 0.09), or good functional outcomes at discharge (93% vs. 92.3%; OR 1.1; 95% CI: 0.45-2.69, p = 0.82).

conclusionNo significant differences in symptomatic stroke rates, perioperative strokes, or functional outcomes were observed between hypertensive and non-hypertensive Moyamoya patients. Appropriate management can lead to similar outcomes in both groups. Further prospective studies are required to validate these findings.

Indexed as

HypertensionMoyamoya DiseasePropensity ScoreAdultCerebral RevascularizationFemaleHumansMaleMiddle AgedRetrospective StudiesStrokeTreatment OutcomeHTNMoyamoyaMulticenterStroke

Identifiers

PMID39269654
PMCPMC11399283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.