Discordant myocardial perfusion defects and coronary artery disease - a multimodality imaging journey in the natural history of cardiac sarcoidosis.

Andrei Galafton, Ronny R Buechel, Fran Mikulicic, Philipp A Kaufmann, Andreas A Giannopoulos

Abstract readCase Reports

In one paragraph

Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrei GalaftonNuclear Medicine Department, Cardiac Imaging, University Hospital Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.

Ronny R BuechelNuclear Medicine Department, Cardiac Imaging, University Hospital Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.

Fran MikulicicDepartment of Cardiology, University Heart Center, University Hospital Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.

Philipp A KaufmannNuclear Medicine Department, Cardiac Imaging, University Hospital Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.

Andreas A GiannopoulosNuclear Medicine Department, Cardiac Imaging, University Hospital Zurich, Raemistrasse 100, Zurich, 8091, Switzerland. andreas.giannopoulos@usz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac sarcoidosis is a rare form of systemic sarcoidosis characterized by formation of non-caseating granulomas in the myocardium, leading to heterogeneous manifestations, including conduction disturbances, arrhythmias, and heart failure. Besides myocardial fibrosis and structural myocardial alterations, cardiac sarcoidosis can impact the epicardial and microvascular circulation, causing ischemia and regional microvascular dysfunction. We present a case of cardiac sarcoidosis with atypical initial presentation but with evidence of disease in myocardial perfusion imaging, which was overlooked since it did not correspond to bystander coronary artery disease. Multimodality imaging facilitated diagnosis and offered insights into the regional microcirculation impairment caused by sarcoidosis-induced inflammation.

Indexed as

CardiomyopathiesCoronary Artery DiseaseCoronary CirculationMultimodal ImagingMyocardial Perfusion ImagingSarcoidosisCoronary AngiographyHumansMicrocirculationPredictive Value of TestsCardiac sarcoidosisDiscordanceInflammationMicrovascular diseaseMyocardial perfusion defectsPET

Identifiers

PMID39269652

DOI10.1007/s10554-024-03232-6

PMCPMC11748477

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.