ArticleEuropean radiology2025
MRI characteristics predict risk of pathological upgrade in patients with ISUP grade group 1 prostate cancer.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Exploring the feasibility of inferring prostate cancer pathological grade from multiparametric MRI text reports using natural language processing: assessment of four large language models.Abdominal radiology (New York) · 2026Article
- Diagnostic discordance in outside prostate biopsies: Implications for active surveillance patient selection.Investigative and clinical urology · 2026Article
- Successes and challenges in developing a magnetic resonance imaging-transrectal ultrasound machine fusion prostate biopsy service.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Review
- Predictive value of theAnnals of nuclear medicine · 2026Article
- Possible Role of Diffusion-Weighted Imaging in Prediction of Prostate Cancer Grade Group Upgrading: Insights from Biopsy to Radical Prostatectomy.Medicina (Kaunas, Lithuania) · 2026Article
- Diagnostic value of prostate magnetic resonance imaging in men with prostate-specific antigen levels ≥ 15 ng/mL for biopsy decision-making.Insights into imaging · 2026Article
- Comparative outcomes of focal HIFU versus active surveillance in low- and intermediate-risk localized prostate cancer: a 75-month retrospective cohort study.Frontiers in urology · 2026Article
- Radical prostatectomy outcomes in patients with PI-RADS 5 lesions and favorable prostate cancer.World journal of urology · 2025Article
- Article
- Multiparametric MRI combined with PSA density as a noninvasive rule-out strategy in active surveillance for prostate cancer.BJUI compass · 2025Article
- Significance of multi-task deep learning neural networks for diagnosing clinically significant prostate cancer in plain abdominal CT.Frontiers in oncology · 2025Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to analyse multiparametric MRI (mpMRI) characteristics of patients diagnosed with ISUP grade group (GG) 1 prostate cancer (PC) on initial target plus systematic MRI/TRUS fusion-guided biopsy and investigate histopathological progression during follow-up.
methodsA retrospective single-centre cohort analysis was conducted on consecutive patients with mpMRI visible lesions (PI-RADS ≥ 3) and detection of ISUP-1-PC at the time of initial biopsy. The study assessed clinical, mpMRI, and histopathological parameters. Subcohorts were analysed with (1) patients who had confirmed ISUP-1-PC and (2) patients who experienced histopathological upgrading to ISUP ≥ 2 PC during follow-up either at re-biopsy or radical prostatectomy (RP).
resultsA total of 156 patients (median age 65 years) between March 2014 and August 2021 were included. Histopathological upgrading to ISUP ≥ 2 was detected in 55% of patients during a median follow-up of 9.5 months (IQR 2.2-16.4). When comparing subgroups with an ISUP upgrade and sustained ISUP 1 PC, they differed significantly in contact length of the index lesion to the pseudocapsule, ADC value, PI-RADS category, and the MRI grading group (mGG) (p < 0.05). In the ISUP GG ≥ 2 subgroup, 91% of men had PI-RADS category 4 or 5 and 82% exhibited the highest mGG (mGG3). In multivariate analysis, mGG was the only independent parameter for predicting ISUP ≥ 2-PC in these patients.
conclusionsMRI reveals important information about PC aggressiveness and should be incorporated into clinical decision-making when ISUP-1-PC is diagnosed. In cases of specific MRI characteristics adverse to the histopathology, early re-biopsy might be considered. CLINICAL RELEVANCE STATEMENT: In cases with clear MRI characteristics for clinically significant prostate cancer (e.g., mGG 3 and/or PI-RADS 5, cT3, or clear focal PI-RADS 4 lesions on MRI) and ISUP GG 1 PC diagnosed on initial prostate biopsy, MRI findings should be incorporated into clinical decision-making and early re-biopsy (e.g., within 6 months) might be considered. KEY POINTS: MRI reveals important information about prostate cancer (PC) aggressiveness. MRI should be incorporated into clinical decision-making when ISUP GG 1 PC is diagnosed on initial prostate biopsy. In cases of specific MRI characteristics adverse to the histopathology, early re-biopsy might be considered.
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