Evidence map›Paper›PMID 39269453›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Cardiac lymphatics undergo distinct remodeling during hypertrophic and nonhypertrophic pregnancy.

Bryan M Kistner, Yanna Tian, Elizabeth S Douglas, Kathleen M Caron

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Normal cardiac lymphatics and their mimics.American journal of physiology. Heart and circulatory physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bryan M KistnerDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.
Yanna TianDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.ORCID 0000-0003-0374-1325
Elizabeth S DouglasDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.
Kathleen M CaronDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.ORCID 0000-0002-7033-9232

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Adrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8M
Cardiac Lymphatics in Heart FailureR01HL129086 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2016 to 2023
$4.1M
American Heart Association (AHA) 24POST1188946American Heart Association-American Stroke Association 24POST1188946American Physical Society (APS) Postdoctoral FellowshipHHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD060860HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL1290986NCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL129086NICHD NIH HHS P50 HD103573NICHD NIH HHS R01 HD060860NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

Lymphatic vessels of the heart undergo dynamic remodeling in response to physiological and pathological cardiovascular events such as development, adult cardiac maintenance, and injury repair. During pregnancy, the cardiovascular system undergoes physiological changes to meet the increased demand for blood supply to the fetus. These extensive physiological changes make pregnancy and delivery a high-risk period in a woman's life. However, whether and how cardiac lymphatics change during pregnancy is largely undefined. Therefore, we used whole mount immunofluorescent labeling and quantitative morphometric analysis to characterize the changes in cardiac lymphatic vasculature during pregnancy using two genetically distinct inbred mouse strains, C57BL/6J and BALB/cJ. When compared with age-matched, nonpregnant C57BL/6J control mice, the hearts of C57BL/6J dams in late pregnancy [

Indexed as

CardiomegalyLymphatic VesselsMice, Inbred BALB CMice, Inbred C57BLAnimalsFemaleGestational AgeMiceMyocardiumPregnancycardiac hypertrophylymphaticsmousepregnancyvasculature

Identifiers

PMID39269453
PMCPMC11560070

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.