ArticleAmerican journal of physiology. Heart and circulatory physiology2024
Adeno-associated virus-mediated gene delivery of
Karthi Sreedevi, Alexey V Zaitsev, Abigail Doku, Rebekah Thomas, Amina James, Sara Do, Mei Zhang, Meghan W Sedovy, Xinyan Leng, Clare L Dennison and 4 more
Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Karthi SreedeviFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Alexey V ZaitsevFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.ORCID 0000-0002-8139-1378
Abigail DokuFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.ORCID 0000-0001-7585-7330
Rebekah ThomasFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Amina JamesFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Sara DoFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Mei ZhangFralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, Virginia, United States.
Meghan W SedovyFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Xinyan LengFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Clare L DennisonFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.
Scott R JohnstoneFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.ORCID 0000-0003-1920-5033
Jonathan A KirkDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States.ORCID 0000-0002-5192-2860
Zhen YanDepartment of Human Nutrition, Food and Exercise, Virginia Tech, Blacksburg, Virginia, United States.ORCID 0000-0002-4826-9813
Junco S WarrenFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.ORCID 0000-0001-5231-4181
Funding
p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
GSK-3β Localizes to the Myofilament and Modifies its Function in Ischemic CardiomyopathyR01HL136737 · NHLBI · UNIVERSITY OF CHICAGO · PI JONATHAN A KIRK · 2017 to 2026
$4.5M
mitoAMPK in exercise benefitsR01AR077440 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2020 to 2024
$2.1M
Structural and functional basis of myocardial dysregulation in genetic cardiomyopathyR01HL172492 · NHLBI · UNIVERSITY OF CHICAGO · PI THOMAS C IRVING, JONATHAN A KIRK · 2024 to 2026
$2.1M
Perm1 is a Novel Regulator of Cardiac Energetics and FunctionR01HL156667 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DRAKOS, STAVROS GEORGE, WARREN, JUNKO SHIBAYAMA · 2021 to 2024
$2.0M
The role of endothelial connexins in vascular wound repairF31HL170721 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SEDOVY, MEGHAN W · 2023 to 2024
$86k
American Heart Association (AHA) 24POST1186520HHS | National Institutes of Health (NIH) NIH R01AR050429HHS | National Institutes of Health (NIH) NIH R01AR077440HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH 1F31HL170721-01HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01HL156667HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01HL15667-02SNHLBI NIH HHS F31 HL170721NHLBI NIH HHS R01 HL136737NHLBI NIH HHS R01 HL156667NHLBI NIH HHS R01 HL172492NIAMS NIH HHS R01 AR050429NIAMS NIH HHS R01 AR077440
6 · The paper itself
Abstract
Reduced muscle contractility and mitochondrial bioenergetics are the hallmarks of systolic heart failure. There is currently no therapy targeting both. Here, we show that gene delivery of
Indexed as
DependovirusMice, Inbred C57BLMitochondria, HeartMyocardial ContractionAnimalsEnergy MetabolismGenetic TherapyGenetic VectorsGene Transfer TechniquesHeart Failure, SystolicMaleMiceMyocytes, CardiacAAVcardiac contractilitymitochondrial bioenergeticsPERM1troponin C
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Adeno-associated virus-mediated gene delivery of · full record | OpenQuestion