Evidence map›Paper›PMID 39269443›Full record

ArticleeLife2024

The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection.

Arijit Chakraborty, Arunava Bandyopadhaya, Vijay K Singh, Filip Kovacic, Sujin Cha, William M Oldham, A Aria Tzika, Laurence G Rahme

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Frontiers in immunology · 2025
    Review
  7. Revealing the impact ofFrontiers in immunology · 2025
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arijit Chakraborty *Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-0883-6385
Arunava Bandyopadhaya *Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.
Vijay K SinghDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0003-4872-4545
Filip KovacicDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-0313-427X
Sujin ChaDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.
William M OldhamDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
A Aria TzikaDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.
Laurence G RahmeDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-5374-4332

Funding

Molecular and Metabolic inter-kingdom actions of a bacterial quorum sensing signal in promotion of host tolerance/resilience.R01AI134857 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2018 to 2022
$3.4M
A comprehensive investigation of Pseudomonas quorum sensing regulatory relationships and the consequences on quorum sensing inhibitors in complex communitiesR01AI177555 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LAURENCE G RAHME · 2023 to 2026
$3.4M
National Institute of Allergy and Infectious Diseases R01AI134857NIAID NIH HHS R01 AI134857NIAID NIH HHS R01 AI177555Shriners Hospitals for Children 83009Shriners Hospitals for Children 85132
6 · The paper itself

Abstract

How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that

Indexed as

Energy MetabolismMacrophagesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPseudomonas aeruginosaQuorum SensingAcetophenonesAnimalsHumansImmune ToleranceMiceMitochondriaPseudomonas InfectionsReceptors, EstrogenAcetophenonesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptors, Estrogen2'-aminoacetophenoneEsrraimmunologyinflammationmouseMvfRPqsRpseudomonasPseudomonas aeruginosaquorum sensingtolerance to infection

Identifiers

PMID39269443
PMCPMC11398867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.