Evidence map›Paper›PMID 39269187›Full record

ArticleMovement disorders clinical practice2024

Family History in Parkinson's Disease: A National Cross-Sectional Study.

Federica Arienti, Giovanni Casazza, Giulia Franco, Giulia Lazzeri, Edoardo Monfrini, Alessandro Di Maio, Roberto Erro, Paolo Barone, Filippo Tamma, Elena Caputo and 40 more

Abstract readMulticenter Study
In one paragraph

Article in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Observational
  3. Compound Heterozygous Structural Variants in Cases with Unsolved PRKN-Associated Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Federica ArientiFoundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.ORCID https://orcid.org/0000-0002-9970-8118
Giovanni CasazzaDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Giulia FrancoFoundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.
Giulia LazzeriDino Ferrari Center, Neuroscience Section, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-9912-2002
Edoardo MonfriniFoundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.
Alessandro Di MaioFoundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.
Roberto ErroNeuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana,", University of Salerno, Baronissi (SA), Italy.ORCID https://orcid.org/0000-0002-7800-7419
Paolo BaroneNeuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana,", University of Salerno, Baronissi (SA), Italy.
Filippo TammaDepartment of Neurology, "F. Miulli" General Hospital, Acquaviva delle Fonti, Italy.
Elena CaputoDepartment of Neurology, "F. Miulli" General Hospital, Acquaviva delle Fonti, Italy.
Maria Antonietta VolontèDepartment of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Laura CacciaguerraDepartment of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea PilottoNeurology Unit and Neurobiorepository and Laboratory of Advanced Biological Markers, Department of Clinical and Experimental Sciences, University of Brescia, and Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia Hospital, Brescia, Italy.ORCID https://orcid.org/0000-0003-2029-6606
Alessandro PadovaniNeurology Unit and Neurobiorepository and Laboratory of Advanced Biological Markers, Department of Clinical and Experimental Sciences, University of Brescia, and Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia Hospital, Brescia, Italy.
Cristoforo ComiDepartment of Translational Medicine, Section of Neurology, University of Piemonte Orientale, Novara, Italy.
Luca MagistrelliGaetano Pini-CTO, Parkinson Institute, Milan, Italy.ORCID https://orcid.org/0000-0002-9546-8567
Franco ValzaniaNeurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Francesco CavallieriNeurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.ORCID https://orcid.org/0000-0001-5836-1982
Laura AvanzinoDepartment of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0001-6286-1509
Roberta MarcheseIRCCS Ospedale Policlinico San Martino-UOC Genetica Medica, Genoa, Italy.
Mariachiara SensiDepartment of Neuroscience and Rehabilitation, Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy.ORCID https://orcid.org/0000-0002-6434-5433
Giorgia CarroliDepartment of Neuroscience and Rehabilitation, Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy.
Roberto EleopraFondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Movement Disorders Unit, Milan, Italy.
Roberto CiliaFondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Movement Disorders Unit, Milan, Italy.ORCID https://orcid.org/0000-0002-1990-1939
Francesca SpagnoloNeurological Department, A. Perrino's Hospital, Brindisi, Italy.
Alessandro TessitoreDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Rosa De MiccoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.ORCID https://orcid.org/0000-0002-6397-8888
Roberto CeravoloUnit of Neurology, Department of Clinical and Experimental MedicineCenter for Neurodegenerative Diseases-Parkinson's Disease and Movement Disorders, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0003-1412-9406
Giovanni PalermoUnit of Neurology, Department of Clinical and Experimental MedicineCenter for Neurodegenerative Diseases-Parkinson's Disease and Movement Disorders, University of Pisa, Pisa, Italy.
Maria Chiara MalagutiNeurology Unit, Trento Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
Leonardo LopianoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
Pierluigi ToccoNeurology and Stroke Unit, Pescara Hospital, Pescara, Italy.
Chiara SorberaNeurorehabilitation Unit IRCCS Centro Neurolesi "Bonino Pulejo," Messina, Messina, Italy.
Michele TinazziDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-2370-7063
Andrea CiammolaDepartment of Neurology and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Donatella OttavianiNeurology Unit, Rovereto Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
Enza Maria ValenteDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0002-0600-6820
Alberto AlbaneseDepartment of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID https://orcid.org/0000-0002-5864-0006
Fabio BlandiniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Margherita CanesiDepartment of Parkinson's Disease, Movement Disorders and Brain Injury Rehabilitation, Moriggia Pelascini Hospital, Gravedona, Italy.
Angelo AntoniniParkinson and Movement Disorders Unit, Center for Neurodegenerative Diseases (CENSE), Department of Neuroscience, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0003-1040-2807
Miryam CarecchioParkinson and Movement Disorders Unit, Center for Neurodegenerative Diseases (CENSE), Department of Neuroscience, University of Padua, Padua, Italy.
Vincenza FetoniNeurology Department, ASST Fatebenefratelli Sacco, Milan, Italy.
Carlo ColosimoDepartment of Neurology, Santa Maria Hospital, Terni, Italy.
Daniele VolpeDepartment of Neurorehabilitation, Parkinson's Disease Excellence Center, Casa di Cura Villa Margherita via Costacolonna n 1 Arcugnano, Vicenza, Italy.
Nicola TambascoMovement Disorders Center, Neurology Department, Perugia General Hospital and University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0003-1497-4482
Giovanni CossuDepartment of Neuroscience, Brotzu Hospital, Cagliari, Italy.
Mario ZappiaDepartment GF Ingrassia, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-8298-9486
Italian Study Group on Family History in PD
Alessio Di FonzoFoundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.ORCID https://orcid.org/0000-0001-6478-026X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFamily history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.

objectivesWe investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).

methodsA cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.

resultsFamily history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.

conclusionsfPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Indexed as

Parkinson DiseaseAgedAge of OnsetCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseHumansItalyMaleMiddle AgedPrevalenceRisk Factorsbipolar disordercognitive impairmentdepressionfamilial and sporadic Parkinson's diseasefamily historyhyposmia

Identifiers

PMID39269187
PMCPMC11542285

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