Evidence map›Paper›PMID 39269177›Full record

ArticleJournal of virology2024

Fibroblast stromal support model for predicting human papillomavirus-associated cancer drug responses.

Claire D James, Rachel L Lewis, Alexis L Fakunmoju, Austin J Witt, Aya H Youssef, Xu Wang, Nabiha M Rais, Apurva T Prabhakar, J Mathew Machado, Raymonde Otoa and 1 more

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Claire D JamesPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Rachel L LewisPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Alexis L FakunmojuPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Austin J WittPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Aya H YoussefPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Xu WangPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Nabiha M RaisPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Apurva T PrabhakarPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.ORCID 0000-0003-2266-7247
J Mathew MachadoPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Raymonde OtoaPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
Molly L BristolPhilips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University (VCU), Richmond, Virginia, USA.ORCID 0000-0002-4259-8528

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
Estrogen reduces HPV transcription and oncogene expression to target diseaseR03DE029548 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BRISTOL, MOLLY L · 2020 to 2021
$295k
NCI NIH HHS P30 CA016059NIDCR NIH HHS R03 DE029548
6 · The paper itself

Abstract

Currently, there are no specific antiviral therapeutic approaches targeting Human papillomaviruses (HPVs), which cause around 5% of all human cancers. Specific antiviral reagents are particularly needed for HPV-related oropharyngeal cancers (HPV IMPORTANCE: Human papillomavirus-related cancers (HPV

Indexed as

Coculture TechniquesEstrogen Receptor alphaFibroblastsPapillomavirus InfectionsAntineoplastic AgentsCell Line, TumorEstrogensHuman Papillomavirus VirusesHumansKeratinocytesOropharyngeal NeoplasmsPapillomaviridaeSelective Estrogen Receptor ModulatorsStromal CellsTamoxifenTumor MicroenvironmentAntineoplastic AgentsESR1 protein, humanEstrogen Receptor alphaEstrogensSelective Estrogen Receptor ModulatorsTamoxifenERαestrogenHPVhuman papillomavirusoropharyngeal cancerraloxifenestromatamoxifentherapeutics

Identifiers

PMID39269177
PMCPMC11494926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.