ArticleNanomaterials (Basel, Switzerland)2024
Potential of Enzymatically Synthesized Hemozoin Analog as Th1 Cell Adjuvant.
Kazuaki Hoshi, Anh Thi Tram Tu, Miwako Shobo, Karin Kettisen, Lei Ye, Leif Bülow, Yoji Hakamata, Tetsuya Furuya, Ryutaro Asano, Wakako Tsugawa and 3 more
Abstract read
In one paragraphArticle in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Kazuaki HoshiResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan.
Anh Thi Tram TuResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan.
Miwako ShoboResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan.
Karin KettisenDivision of Pure and Applied Biochemistry, Department of Chemistry, Lund University, 22100 Lund, Sweden.
Lei YeDivision of Pure and Applied Biochemistry, Department of Chemistry, Lund University, 22100 Lund, Sweden.ORCID 0000-0002-3646-4072 Leif BülowDivision of Pure and Applied Biochemistry, Department of Chemistry, Lund University, 22100 Lund, Sweden.ORCID 0000-0003-4966-8610 Yoji HakamataSchool of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Musashino 180-8602, Japan.ORCID 0000-0002-0138-6692 Tetsuya FuruyaCooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu 183-8509, Japan.ORCID 0000-0003-3979-7072 Ryutaro AsanoDepartment of Biotechnology and Life science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei 184-8588, Japan.ORCID 0000-0001-6795-8377 Wakako TsugawaDepartment of Biotechnology and Life science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei 184-8588, Japan.ORCID 0000-0001-6299-5267 Kazunori IkebukuroDepartment of Biotechnology and Life science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei 184-8588, Japan.ORCID 0000-0003-2838-0562 Koji SodeJoint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9833-2091 Tomohiko YamazakiResearch Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan.ORCID 0000-0003-2136-8042 Funding
Japan Society for the Promotion of Science 15K06589Japan Society for the Promotion of Science 17KK0122Tsukuba Clinical Research＆Development Organization A18-58
6 · The paper itselfAbstract
Hemozoin (Hz) is a heme crystal produced during malaria infection that stimulates immune cells, leading to the production of cytokines and chemokines. The immunostimulatory action of Hz has previously been applied in the development of alternative adjuvants. Crystallization of hemin is a chemical approach for producing Hz. Here, we focused on an enzymatic production method for Hz using the heme detoxification protein (HDP), which catalyzes heme dimer formation from hemin in
Indexed as
adjuvantheme detoxification proteinhemozoin analogTh-1 immunityvaccine
Identifiers
PMID39269102
PMCPMC11397214
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