Evidence map›Paper›PMID 39269097›Full record

ArticleNanomaterials (Basel, Switzerland)2024

Size-Dependent Internalization of Microplastics and Nanoplastics Using In Vitro Model of the Human Intestine-Contribution of Each Cell in the Tri-Culture Models.

Hyunjin Choi, Shohei Kaneko, Yusei Suzuki, Kosuke Inamura, Masaki Nishikawa, Yasuyuki Sakai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Microplastics and Nanoplastics in Food: Dietary Toxicology Beyond Particle Counts.Comprehensive reviews in food science and food safety · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hyunjin ChoiDepartment of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.ORCID 0000-0001-8795-0970
Shohei KanekoDepartment of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.
Yusei SuzukiDepartment of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.
Kosuke InamuraDepartment of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.
Masaki NishikawaDepartment of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.ORCID 0000-0003-4253-3211
Yasuyuki SakaiDepartment of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Tokyo 113-8656, Japan.ORCID 0000-0002-2249-6516

Funding

The University of Tokyo FSI - Nippon Foundation Research Project on Marine Plastics none
6 · The paper itself

Abstract

Pollution by microplastics and nanoplastics (MNPs) raises concerns, not only regarding their environmental effects, but also their potential impact on human health by internalization via the small intestine. However, the detailed pathways of MNP internalization and their toxicities to the human intestine have not sufficiently been understood, thus, further investigations are required. This work aimed to understand the behavior of MNPs, using in vitro human intestine models, tri-culture models composed of enterocyte Caco-2 cells, goblet-like HT29-MTX-E12 cells, and microfold cells (M cells) induced by the lymphoblast cell line Raji B. Three sizes (50, 100, and 500 nm) of polystyrene (PS) particles were exposed as MNPs on the culture model, and size-dependent translocation of the MNPs and the contributions of each cell were clarified, emphasizing the significance of the tri-culture model. In addition, potential concerns of MNPs were suggested when they invaded the circulatory system of the human body.

Indexed as

absorption pathwayco-cultureenterocytegoblet cellsintestine culture modelin vitro modelM cellsmicroplasticsnanoplasticssize dependencetri-culture

Identifiers

PMID39269097
PMCPMC11397364

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.