Evidence map›Paper›PMID 39268839›Full record

ReviewBiotechnology progress

Optimizing cryopreservation strategies for scalable cell therapies: A comprehensive review with insights from iPSC-derived therapies.

Michael Dobruskin, Geoffrey Toner, Ronald Kander

Abstract readReview
In one paragraph

Review in Biotechnology progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael DobruskinJefferson Institute for Bioprocessing, Thomas Jefferson University, Spring House, Pennsylvania, USA.ORCID 0009-0005-0347-947X
Geoffrey TonerJefferson Institute for Bioprocessing, Thomas Jefferson University, Spring House, Pennsylvania, USA.
Ronald KanderJefferson Institute for Bioprocessing, Thomas Jefferson University, Spring House, Pennsylvania, USA.

Funding

Thomas Jefferson University
6 · The paper itself

Abstract

Off-the-shelf cell therapies hold significant curative potential for conditions, such as Parkinson's disease and heart failure. However, these therapies face unique cryopreservation challenges, especially when novel routes of administration, such as intracerebral or epicardial injection, require cryopreservation media that are safe for direct post-thaw administration. Current practices often involve post-thaw washing to remove dimethyl sulfoxide (Me

Indexed as

Cell- and Tissue-Based TherapyCryopreservationCryoprotective AgentsInduced Pluripotent Stem CellsAnimalsCell SurvivalDimethyl SulfoxideHumansCryoprotective AgentsDimethyl Sulfoxidecell therapycryopreservationDMSO‐freeinduced pluripotent stem cellsoff‐the‐shelf

Identifiers

PMID39268839
PMCPMC11659802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.