Evidence map›Paper›PMID 39268586›Full record

ArticleTransfusion2024

Use of low titer O whole blood in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.

Massimo Griselli, Sameh M Said, Philip C Spinella, Michael Evans, Claudia S Cohn, Nitasha Joyner, Martina Richtsfeld, Kayla Fahey-Arndt, Julie Welbig, Greg Beilman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Massimo GriselliDepartment of Cardio-Thoracic Surgery, Cardiac Surgery, King Abdullah bin Abdulaziz University Hospital and Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Sameh M SaidDepartment of Surgery, Pediatric and Adult Congential Cardiac Surgery, Maria Fareri Children's Hospital and Westchester Medical Center, Valhalla, New York, USA.ORCID 0000-0003-2193-0314
Philip C SpinellaDepartment of Surgery, Trauma and Transfusion Medicine Research Center, Center for Military Medicine Research, University of Pittsburgh, Pittsburrgh, Pennsylvania, USA.ORCID 0000-0003-1721-0541
Michael EvansClinical and Translational Science Institute, Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Claudia S CohnDivision of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-9847-0470
Nitasha JoynerCardiac Surgery, Medtronic, Brooklyn Park, Minnesota, USA.
Martina RichtsfeldDivision of Pediatric Cardiac Anesthesia, Department of Anesthesiology, University of Minnesota, Masonic Children's Hospital, Minneapolis, Minnesota, USA.
Kayla Fahey-ArndtDivision of Laboratory Medicine and Pathology, Transfusion Medicine, Fairview Health Services, Minneapolis, Minnesota, USA.
Julie WelbigM Health Fairview, Minneapolis, Minnesota, USA.
Greg BeilmanDepartment of Surgery, Minnesota Translational Center for Resuscitative Trauma Care, University of Minnesota, Minneapolis, Minnesota, USA.
Nicole D ZantekDivisión of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Marie E SteinerDivision of Pediatric Hematology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4169-1920

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494NIH HHS UL1TR002494
6 · The paper itself

Abstract

backgroundLow titer group O whole blood (LTOWB) is commonly used for severe bleeding in trauma patients. LTOWB may also benefit young children requiring cardiac surgery with cardiopulmonary bypass (CPB) at risk of severe bleeding. STUDY DESIGN AND

methodsIn this retrospective study, children <2 years old who underwent cardiac surgery with CPB were included. Comparisons were performed between those receiving component therapy (CT) versus those receiving LTOWB plus CT (LTOWB+CT). Outcomes included drainage tube (DT) output and total transfusion volumes. Optimization-based weighting was used for adjusted analyses between groups.

resultsThere were 117 patients transfused with only CT and 127 patients transfused with LTOWB+CT. In the LTOWB+CT group, 66 were Group non-O and 61 were Group O. Total transfusion volumes given from the start of the operation until the first 24 h in the cardiac intensive care unit was a median (IQR) 41 (10, 93) mL/kg in the CT group and 48 (28, 77) mL/kg in the LTOWB+CT group, (p = .28). Median (IQR) DT output was 22 (15-32) in CT versus 22 (16-28) in LTOWB+CT groups, (p = .27). There were no differences in death, renal failure and a composite of death and renal failure between the two groups, but there were statistically fewer re-explorations for bleeding in the LTOWB+CT group (p < .001).

conclusionsThe use of LTOWB appears to be safe in <2 years old undergoing cardiac surgery and may reduce re-explorations for severe bleeding. Large trials are needed to determine the efficacy and safety of LTOWB in this population with severe bleeding.

Indexed as

ABO Blood-Group SystemBlood TransfusionCardiac Surgical ProceduresCardiopulmonary BypassFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesABO Blood-Group Systemcardiac surgerycardiopulmonary bypass (CPB)childreninfantslow titer group O whole bloodLTOWBneonates

Identifiers

PMID39268586
PMCPMC11573636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.