ArticleWellcome open research2022
Inflammation proteomics datasets in the ALSPAC cohort.
Article in Wellcome open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes.Nature metabolism · 2026Article
- Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity.Nature communications · 2026Article
- Impact of clinical factors and season on inflammatory cytokines in biologic-treated and untreated asthma.Respiratory research · 2025Article
- Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults.Brain, behavior, and immunity · 2025Article
- Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women.Communications medicine · 2025Article
- Metabotype identification via fasting and postprandial metabolomics and its association with type 2 diabetes incidence.Cardiovascular diabetology · 2025Article
- DNA methylation models of protein abundance across the lifecourse.Clinical epigenetics · 2024Article
- Inflammation proteomics datasets in the ALSPAC cohort.Wellcome open research · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
Proteomics is the identification, detection and quantification of proteins within a biological sample. The complete set of proteins expressed by an organism is known as the proteome. The availability of new high-throughput proteomic technologies, such as Olink Proteomic Proximity Extension Assay (PEA) technology has enabled detailed investigation of the circulating proteome in large-scale epidemiological studies. In particular, the Olink® Target 96 inflammatory panel allows the measurement of 92 circulating inflammatory proteins. The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1991-1992 and has followed these women, their partners, and their offspring ever since. In this data note, we describe the newly-released proteomic data available in ALSPAC. Ninety-two proteins were analysed in 9000 blood plasma samples using the Olink® Target 96 inflammatory panel. Samples were derived from 2968 fasted mothers (mean age 47.5; Focus on Mothers 1 (FOM1)), 3005 non-fasted offspring at age 9 (Focus@9) and 3027 fasted offspring at age 24 (Focus@24). Post sample filtering, 1834 offspring have data at both timepoints and 1119 of those have data from their mother available. We performed quality control analyses using a standardised data processing workflow (
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