Evidence map›Paper›PMID 39268319›Full record

ArticleCureus2024

Facial Skin Manifestation of a Destructive, Nonkeratinizing Squamous Cell Carcinoma.

Vixey Silva, Richard G Bindernagel, Melissa Cheng, Richard Miller

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vixey SilvaDermatology, HCA Healthcare/University of South Florida (USF) Morsani College of Medicine: Largo Medical Center Program, Largo, USA.
Richard G BindernagelDermatology, HCA Healthcare/University of South Florida (USF) Morsani College of Medicine: Largo Medical Center Program, Largo, USA.
Melissa ChengDermatology, Western University of Health Sciences, Pomona, USA.
Richard MillerDermatology, HCA Healthcare/University of South Florida (USF) Morsani College of Medicine: Largo Medical Center Program, Largo, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonkeratinizing squamous cell carcinoma (NKSCC) of the sinonasal tract is a rare malignancy that infrequently presents with cutaneous extension. This case describes an unusual instance of extensive facial skin involvement in an elderly male with multiple comorbidities, diagnosed with a biopsy-proven NKSCC. The tumor was p16 positive, suggesting an HPV-related etiology. This case emphasizes the critical role of dermatologists in the early diagnosis and multidisciplinary management of such aggressive tumors. It highlights the necessity of including NKSCC in the differential diagnosis of destructive facial tumors. Dermatologists should remain vigilant for rare presentations and employ early biopsy and histopathological examinations to facilitate prompt multidisciplinary intervention. Recognizing p16 positivity can indicate a human papillomavirus (HPV)-related etiology, potentially influencing prognosis and management strategies.

Indexed as

aggressive destructive lesionhpv-related oropharyngeal cancernasopharyngeal biopsyp16 testingsquamous cell carcinoma

Identifiers

PMID39268319
PMCPMC11392562

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.