Evidence map›Paper›PMID 39268067›Full record

ReviewFrontiers in neurology2024

Epilepsy insights revealed by intravital functional optical imaging.

Matthew A Stern, Raymond Dingledine, Robert E Gross, Ken Berglund

Abstract readReview
In one paragraph

Review in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew A SternDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States.
Raymond DingledineDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, United States.
Robert E GrossDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States.
Ken BerglundDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States.

Funding

Seizure EngramR21NS112948 · NINDS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 2020 to 2021
$468k
Harnessing Calcium Influx to Visualize and Regulate Seizure NetworksF31NS115479 · NINDS · EMORY UNIVERSITY · PI STERN, MATTHEW ALEXANDER · 2020 to 2022
$122k
NINDS NIH HHS F31 NS115479NINDS NIH HHS R21 NS112948
6 · The paper itself

Abstract

Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain millions of patients suffering from poorly controlled seizures. One approach to closing this treatment gap may be found through a deeper mechanistic understanding of the network alterations that underly this aberrant activity. Functional optical imaging in vertebrate models provides powerful advantages to this end, enabling the spatiotemporal acquisition of individual neuron activity patterns across multiple seizures. This coupled with the advent of genetically encoded indicators, be them for specific ions, neurotransmitters or voltage, grants researchers unparalleled access to the intact nervous system. Here, we will review how

Indexed as

GECIGEVIin vivo imaginglight sheetneurophotonicsseizuretwo-photonwidefield

Identifiers

PMID39268067
PMCPMC11390408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.