Evidence map›Paper›PMID 39267791›Full record

ArticleTheranostics2024

Amide naphthotube as a novel supramolecular sequestration agent for tetracaine and decamethonium.

Cheng-Da Zhao, Wei Cai, Wen-Jie Chen, Huan Yao, Song-Meng Wang, Kailin Li, Yan-Long Ma, Li-Li Wang, Liu-Pan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng-Da ZhaoThe Affiliated Nanhua Hospital, School of Pharmaceutical Science and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Wei CaiSchool of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, 418000, China.
Wen-Jie ChenThe Affiliated Nanhua Hospital, School of Pharmaceutical Science and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Huan YaoThe Affiliated Nanhua Hospital, School of Pharmaceutical Science and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Song-Meng WangDepartment of Chemistry, Southern University of Science and Technology, Xueyuan Blvd 1088, Shenzhen, 518055, China.
Kailin LiSchool of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, 418000, China.
Yan-Long MaSchool of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University, Zhongshan 528458, China.
Li-Li WangThe Affiliated Nanhua Hospital, School of Pharmaceutical Science and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Liu-Pan YangThe Affiliated Nanhua Hospital, School of Pharmaceutical Science and School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAnesthetics are widely used for optimizing surgical conditions, postoperative pain management, and treating various chronic pain conditions. Tetracaine and decamethonium are representative drugs of local anesthetics and neuromuscular blocking agents, respectively. However, overdose and toxicity of the drugs always lead to serious adverse events. Thus, there is a strong demand for effective antidotes.

methodsThe binding interactions of amide naphthotubes with tetracaine and decamethonium were systematically studied using

resultsWe have demonstrated that the anti-isomer of amide naphthotube exhibits significant binding affinities towards tetracaine (

conclusionAn emerging artificial receptor, amide naphthotube, has strong binding affinities towards tetracaine and decamethonium. It functions as a supramolecular antidote for tetracaine poisoning and a reversal agent for decamethonium by selectively sequestering these compounds in vivo.

Indexed as

AntidotesTetracaineAmidesAnesthetics, LocalAnimalsHumansMaleMiceNeuromuscular Blocking AgentsAmidesAnesthetics, LocalAntidotesNeuromuscular Blocking AgentsTetracaineamide naphthotubedecamethoniumdetoxificationsupramolecular sequestrationtetracaine

Identifiers

PMID39267791
PMCPMC11388068

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.