Evidence map›Paper›PMID 39267749›Full record

ArticleFrontiers in immunology2024

Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers.

Eva Poveda, Wendy Fitzgerald, Jacobo Alonso-Domínguez, José Aguayo-Arjona, Ana Mariño, Hortensia Álvarez, Nieves Valcarce, Alexandre Pérez, Ezequiel Ruiz-Mateos, Leonid Margolis and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The elite controller phenotype.Current opinion in HIV and AIDS · 2026
    Review
  2. Article
  3. Persistent CD8Frontiers in immunology · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eva PovedaGroup of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
Wendy FitzgeraldSection on Intercellular Interactions, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Jacobo Alonso-DomínguezGroup of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
José Aguayo-ArjonaStatistics and Methodology Unit, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
Ana MariñoComplexo Hospitalario Universitario de Ferrol, Sergas, A Coruña, Spain.
Hortensia ÁlvarezComplexo Hospitalario Universitario de Ferrol, Sergas, A Coruña, Spain.
Nieves ValcarceComplexo Hospitalario Universitario de Ferrol, Sergas, A Coruña, Spain.
Alexandre PérezGroup of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
Ezequiel Ruiz-MateosInstitute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University of Seville, Seville, Spain.
Leonid MargolisFaculty of Natural Sciences and Medicine, Ilia State University, Tbilisi, Georgia.
Michael M LedermanDepartment of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Michael L FreemanDepartment of Medicine, Case Western Reserve University, Cleveland, OH, United States.

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
Viral transmission and pathogenesis in human tissuesZIAHD008968 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARGOLIS, LEONID B. · 2018 to 2023
$12.2M
Intramural NIH HHS ZIA HD008968NIAID NIH HHS P30 AI036219
6 · The paper itself

Abstract

Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.

Indexed as

BiomarkersChemokine CXCL10Chemokine CXCL9HIV InfectionsAdultFemaleHIV-1HIV Long-Term SurvivorsHumansMaleMiddle AgedViral LoadBiomarkersChemokine CXCL10Chemokine CXCL9CXCL10 protein, humanCXCL9 protein, humanelite controllersfunctional cureHIVIP-10MIG

Identifiers

PMID39267749
PMCPMC11390527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.