Evidence map›Paper›PMID 39267669›Full record

ArticleAmerican journal of cancer research2024

Paraneoplastic leukocytosis induces NETosis and thrombosis in bladder cancer PDX model.

Yung-Chia Kuo, Chen-Yang Huang, Cedric Chuan Young Ng, Chiao-Yun Lin, Wen-Kuan Huang, Li-Yu Lee, Hsien-Chi Fan, An-Chi Lin, Kai-Jie Yu, See-Tong Pang and 2 more

Abstract read
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In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yung-Chia KuoDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Chen-Yang HuangDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Cedric Chuan Young NgIntegrated Genomics Platform, National Cancer Centre Singapore Singapore, The Republic of Singapore.
Chiao-Yun LinGynecologic Cancer Research Center, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Wen-Kuan HuangDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Li-Yu LeeDepartment of Pathology, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Hsien-Chi FanDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
An-Chi LinDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Kai-Jie YuDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
See-Tong PangDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Bin Tean TehInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR) Singapore, The Republic of Singapore.
Cheng-Lung HsuDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University Taoyuan 33305, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic leukocytosis (PNL) in genitourinary cancer, though rare, can indicate aggressive behavior and poor outcomes. It has been potentially linked to cancer expressing G-CSF and GM-CSF, along with their respective receptors, exerting an autocrine/paracrine effect. In our study, we successfully established four patient-derived xenograft (PDX) lines and related cell lines from urothelial cancer (UC), conducting next-generation sequencing (NGS) for genetic studies. UC-PDX-LN1, originating from bladder cancer, exhibited two druggable targets -

Indexed as

autocrinebladder cancerNETosisParaneoplastic leukocytosispatient-derived xenograftthrombosis

Identifiers

PMID39267669
PMCPMC11387854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.