Evidence map›Paper›PMID 39266972›Full record

ArticleBMC geriatrics2024

Cross-sectional association between high-sensitivity C-reactive protein and cognitive function in community-dwelling older adults: the SONIC study.

Mariko Hosokawa, Mai Kabayama, Kayo Godai, Yuya Akagi, Yuka Tachibana, Yasuyuki Gondo, Saori Yasumoto, Yukie Masui, Takumi Hirata, Tatsuro Ishizaki and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mariko HosokawaDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan.
Mai KabayamaDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan.
Kayo GodaiDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan.
Yuya AkagiDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan.
Yuka TachibanaDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan.
Yasuyuki GondoDepartment of Clinical Thanatology and Geriatric Behavioral Sciences, Graduate School of Human Sciences, Osaka University, Osaka, Japan.
Saori YasumotoOffice of International Exchange, Graduate School of Human Sciences, Osaka University, Osaka, Japan.
Yukie MasuiTokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Takumi HirataTokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Tatsuro IshizakiTokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Hiroshi AkasakaDepartment of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yasushi TakeyaDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan.
Yoichi TakamiDepartment of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Koichi YamamotoDepartment of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Masahiro KitamuraDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Kazunori IkebeDepartment of Removable Prosthodontics and Gerodontology, Osaka University Graduate School of Dentistry, Osaka, Japan.
Yasumichi AraiCenter of Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Hiromi RakugiDepartment of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kei KamideDivision of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita, 565-0871, Osaka, Japan. kamide@sahs.med.osaka-u.ac.jp.

Funding

JSPS KAKENHI 19K11138JST SPRING JPMJSP2138
6 · The paper itself

Abstract

backgroundA decline in cognitive function is associated with inflammatory processes. However, the association between high-sensitivity C-reactive protein (hs-CRP) levels and cognitive decline in the Japanese population remains inconclusive. Thus, this study aimed to determine whether hs-CRP is associated with low cognitive function in 70- and 80-year-old community-dwelling Japanese individuals.

methodsThe participants in this cross-sectional study were 872 Japanese residents aged 70 and 80 years who voluntarily participated in the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study between 2010 and 2011. Blood sample collection, cognitive assessment, and other measurements were performed at the venue. Low cognitive function was defined as a score of 25 points or lower on the Japanese version of the Montreal Cognitive Assessment. The odds ratio (OR) and 95% confidence interval (95% CI) for each hs-CRP quartile were calculated using logistic regression analysis.

resultsA total of 288 (69.9%) parsons in the 70-year-old group and 372 (80.9%) in the 80-year-old group exhibited low cognitive function. The association between hs-CRP levels and low cognitive function was significant among 70- and 80-year-old Japanese community-dwelling adults. In particular, the fourth quartile of hs-CRP (0.727-7.420 mg/L) in the 70-year-old group and the second and fourth quartiles (0.214-0.404 and 0.911-9.890 mg/L) in the 80-year-old group were associated with low cognitive function. Furthermore, the third quartile (0.409-0.892 mg/L) in the 80-year-old group was closely associated with low cognitive function.

conclusionsHigh hs-CRP levels were associated with lower cognitive function in 70- and 80-year-old Japanese community-dwelling individuals, suggesting that high hs-CRP levels may influence cognitive function.

Indexed as

CognitionCognitive DysfunctionC-Reactive ProteinIndependent LivingAgedAged, 80 and overBiomarkersCross-Sectional StudiesFemaleHumansJapanMaleBiomarkersC-Reactive ProteinChronic inflammationCognitive impairmentEpidemiologic study in general populationHigh-sensitivity C-reactive proteinMoCA-J

Identifiers

PMID39266972
PMCPMC11395644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.