Evidence map›Paper›PMID 39266927›Full record

Observational studyJournal of clinical monitoring and computing2025

Preoperative biomarkers associated with delayed neurocognitive recovery.

Mariana Thedim, Duygu Aydin, Gerhard Schneider, Rajesh Kumar, Matthias Kreuzer, Susana Vacas

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical monitoring and computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariana Thedim *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street 444GRB, Boston, MA, 02114, USA.
Duygu Aydin *Department of Anesthesiology and Intensive Care Medicine, Technical University of Munich School of Medicine, Munich, Germany.
Gerhard SchneiderDepartment of Anesthesiology and Intensive Care Medicine, Technical University of Munich School of Medicine, Munich, Germany.
Rajesh KumarDepartment of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Matthias KreuzerDepartment of Anesthesiology and Intensive Care Medicine, Technical University of Munich School of Medicine, Munich, Germany.
Susana VacasDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street 444GRB, Boston, MA, 02114, USA. svacas@mgh.harvard.edu.

Funding

Mechanisms Mediating Postoperative Neurocognitive DisordersK23GM132795 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VACAS, SUSANA · 2019 to 2023
$1.0M
Blood Brain Barrier Dysfunction and Perioperative Neurocognitive Disorders in older adultsR21AG070269 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, VACAS, SUSANA · 2020 to 2020
$429k
NIA NIH HHS R21 AG070269NIA NIH HHS R21AG070269NIGMS NIH HHS K23 GM132795NIGMS NIH HHS K23GM132795
6 · The paper itself

Abstract

To identify baseline biomarkers of delayed neurocognitive recovery (dNCR) using monitors commonly used in anesthesia. In this sub-study of observational prospective cohorts, we evaluated adult patients submitted to general anesthesia in a tertiary academic center in the United States. Electroencephalographic (EEG) features and cerebral oximetry were assessed in the perioperative period. The primary outcome was dNCR, defined as a decrease of 2 scores in the global Montreal Cognitive Assessment (MoCA) between the baseline and postoperative period. Forty-six adults (median [IQR] age, 65 [15]; 57% females; 65% American Society of Anesthesiologists (ASA) 3 were analyzed. Thirty-one patients developed dNCR (67%). Baseline higher EEG power in the lower alpha band (AUC = 0.73 (95% CI 0.48-0.93)) and lower alpha peak frequency (AUC = 0.83 (95% CI 0.48-1)), as well as lower cerebral oximetry (68 [5] vs 72 [3], p = 0.011) were associated with dNCR. Higher EEG power in the lower alpha band, lower alpha peak frequency, and lower cerebral oximetry values can be surrogates of baseline brain vulnerability.

Indexed as

BiomarkersCognitionAdultAgedAnesthesia, GeneralBrainCohort StudiesElectroencephalographyFemaleHumansMaleMental Status and Dementia TestsMiddle AgedNeuropsychological TestsOximetryPostoperative PeriodBiomarkersElectroencephalographyGeneral anesthesiaNeuropsychological testsOximetryPostoperative cognitive complicationsSurgery

Identifiers

PMID39266927
PMCPMC11821442

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.