ArticleNature chemical biology2025
Control of DNA demethylation by superoxide anion in plant stem cells.
Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Zinc-finger proteins C3H14 and C3H15 maintain meiocyte identity in flowering plants.Nature plants · 2026Article
- A GRX-SOD module maintains superoxide homeostasis and meristem development in maize.Advanced biotechnology · 2026Article
- Reactive oxygen species and oxidative signalling in plants.Essays in biochemistry · 2026Review
- Microevolution and stress tolerance of Arabidopsis thaliana from the Chernobyl-affected zone.Planta · 2026Article
- Emerging concepts of reactive oxygen species functions in plants.Biochemical Society transactions · 2026Review
- Linking Superoxide Production and Scavenging in Plant Development.Plant, cell & environment · 2026Review
- Metal surface-triggered DNAzyme catalysis for efficient DNA cleavage.Communications chemistry · 2026Article
- The critical importance of accurate chemical notation for the superoxide radical (ONature plants · 2026Article
- DNA methylation dynamics: patterns, regulation, and function.Current opinion in plant biology · 2025Review
- The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Cooling down transposon mobility.Nature plants · 2025Article
- Differential concentrations of NaCl and KFrontiers in plant science · 2025Article
- Functional Analysis ofInternational journal of molecular sciences · 2024Article
- Redox regulation of meristem quiescence: outside/in.Journal of experimental botany · 2024Review
- Superoxide signalling and antioxidant processing in the plant nucleus.Journal of experimental botany · 2024Review
- The ascorbate-glutathione cycle coming of age.Journal of experimental botany · 2024Review
- Cell-cell heterogeneity in phosphoenolpyruvate carboxylase biases early cell fate priming inFrontiers in cell and developmental biology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Superoxide anion is thought to be a natural by-product with strong oxidizing ability in all living organisms and was recently found to accumulate in plant meristems to maintain stem cells in the shoot and undifferentiated meristematic cells in the root. Here we show that the DNA demethylase repressor of silencing 1 (ROS1) is one of the direct targets of superoxide in stem cells. The Fe-S clusters in ROS1 are oxidized by superoxide to activate its DNA glycosylase/lyase activity. We demonstrate that superoxide extensively participates in the establishment of active DNA demethylation in the Arabidopsis genome and that ARABIDOPSIS RESPONSE REGULATOR 12 acts downstream of ROS1-mediated superoxide signaling to maintain stem cell fate. Our results provide a mechanistic framework for superoxide control of the stem cell niche and demonstrate how redox and DNA demethylation interact to define stem cell fate in plants.
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39266722What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.