Evidence map›Paper›PMID 39266682›Full record

ArticleAesthetic plastic surgery2025

Internal Nasal Valve Collapse Treatment by Endonasal Hyaluronic Acid Injection.

Pierre Gagnieur, Maxime Fieux, Laurie Saloner, Bruno Louis, Delphine Vertu-Ciolino, Alain-Ali Mojallal

Abstract read
In one paragraph

Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pierre GagnieurService de chirurgie maxillo-faciale et plastique de la face, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, F-69495, Pierre Bénite cedex, France.
Maxime FieuxService d'ORL d'otoneurochirurgie et de chirurgie cervico-faciale, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, F-69495, Pierre Bénite cedex, France. maxime.fieux@chu-lyon.fr.ORCID 0000-0001-8317-2286
Laurie SalonerService d'ORL et de chirurgie cervico-faciale, Hospices Civils de Lyon, Hôpital Edouard Herriot, F-69003, Lyon, France.
Bruno LouisUniv Paris Est Créteil, INSERM, F-94010, Créteil, IMRB, France.
Delphine Vertu-CiolinoService d'ORL et de chirurgie cervico-faciale, Hospices Civils de Lyon, Hôpital Edouard Herriot, F-69003, Lyon, France.
Alain-Ali MojallalService de Chirurgie Plastique, Esthétique et Réparatrice, Hospices Civils de Lyon, Hôpital Croix Rousse, F-69003, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInternal nasal valve collapse (IVC) is a common functional complication of rhinoplasty and injecting hyaluronic acid is one of the treatment options available, but its effectiveness has never been evaluated. The objective of this study was to assess the evolution of IVC after injection of hyaluronic acid using objective and subjective measures of nasal obstruction. STUDY

designA prospective interventional study was conducted.

methodsAdult patients consulting for nasal obstruction after (septo)rhinoplasty and diagnosed with IVC were included. Patients underwent 4-phase rhinomanometry, completed nasal obstruction symptoms evaluation (NOSE) and visual analog scale (VAS) questionnaires and received hyaluronic acid injections. Measurements were repeated immediately, one month and one year later. The primary outcome measure was the proportion of patients below the rhinomanometric diagnostic threshold for IVC at one month.

resultsAmong the 22 patients included, 20 (91%) had rhinomanometry measurements below the diagnostic threshold for IVC one month after injection. It decreased to 53% (8/15 patients) at one year post injection. The mean NOSE score decreased from 74.5 (± 18.0) before injection to 35.2 (± 23.3) after injection (p < 0.0001). The mean VAS score decreased from 7.0 (± 1.4) before injection to 3.4 (± 1.9) after injection (p < 0.0001). In these patients with post-(septo)rhinoplasty IVC, hyaluronic acid injection into the internal nasal valve substantially improved subjective and objective measures of nasal obstruction.

conclusionThese results suggest hyaluronic acid injection (performed as described) is an effective treatment for IVC and is an excellent alternative to surgical treatment. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .

Indexed as

Hyaluronic AcidNasal ObstructionRhinoplastyAdultCohort StudiesEstheticsFemaleFollow-Up StudiesHumansInjectionsMaleMiddle AgedProspective StudiesRhinomanometryRisk AssessmentTreatment OutcomeHyaluronic AcidNasal airflows dynamicsPost-operativeQuality of lifeTherapeutics

Identifiers

PMID39266682
PMCPMC12069151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.