Evidence map›Paper›PMID 39266605›Full record

ArticleScientific reports2024

Neural basis of false recognition in Alzheimer's disease and dementia with lewy bodies.

Yoshihiro Chadani, Ryoko Fujito, Naohiro Kimura, Ryo Kawai, Tetsuo Kashibayashi, Ryuichi Takahashi, Hideki Kanemoto, Kazunari Ishii, Kenji Tagai, Shunichiro Shinagawa and 2 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yoshihiro ChadaniDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
Ryoko FujitoDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
Naohiro KimuraGraduate School of Integrated Arts and Sciences, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
Ryo KawaiDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
Tetsuo KashibayashiDementia-related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, 1-7-1, Kouto, Shingu-cho, Tatsuno City, Hyogo, 679-5165, Japan.
Ryuichi TakahashiDementia-related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, 1-7-1, Kouto, Shingu-cho, Tatsuno City, Hyogo, 679-5165, Japan.
Hideki KanemotoDepartment of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Kazunari IshiiDepartment of Radiology, Kindai University, Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama City, Osaka, 589-8511, Japan.
Kenji TagaiDepartment of Psychiatry, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8471, Japan.
Shunichiro ShinagawaDepartment of Psychiatry, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8471, Japan.
Manabu IkedaDepartment of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan.
Hiroaki KazuiDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan. kazui@kochi-u.ac.jp.

Funding

Japan Agency for Medical Research and Development JP21dk0207056
6 · The paper itself

Abstract

In Alzheimer's disease (AD), reports on the association between false recognition and brain structure have been inconsistent. In dementia with Lewy bodies (DLB), no such association has been reported. This study aimed to identify brain regions associated with false recognition in AD and DLB by analyzing regional gray matter volume (rGMV). We included 184 patients with AD and 60 patients with DLB. The number of false recognitions was assessed using the Alzheimer's Disease Assessment Scale' word recognition task. Brain regions associated with the number of false recognitions were examined by voxel-based morphometry analysis. The number of false recognitions significantly negatively correlated with rGMV in the bilateral hippocampus, left parahippocampal gyrus, bilateral amygdala, and bilateral entorhinal cortex in patients with AD (p < 0.05, family-wise error [FEW] corrected) and in the bilateral hippocampus, left parahippocampal gyrus, right inferior frontal gyrus, right middle frontal gyrus, right basal forebrain, right insula, left medial and lateral orbital gyri, and left fusiform in those with DLB (p < 0.05, FWE corrected). Bilateral hippocampus and left parahippocampal gyrus were associated with false recognition in both diseases. However, we found there were regions where the association between false recognition and rGMV differed from disease to disease.

Indexed as

Alzheimer DiseaseLewy Body DiseaseMagnetic Resonance ImagingAgedAged, 80 and overBrainFemaleGray MatterHippocampusHumansMaleParahippocampal GyrusRecognition, PsychologyAlzheimer’s dementiaAlzheimer’s Disease Assessment ScaleDementia with Lewy bodiesFalse recognitionStatistical parametric mappingVoxel-based morphometry

Identifiers

PMID39266605
PMCPMC11392955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.