Evidence map›Paper›PMID 39266476›Full record

ArticleExperimental neurobiology2024

Phosphorylated Tau in the Taste Buds of Alzheimer's Disease Mouse Models.

Hyun Ji Kim, Bo Hye Kim, Dong Kyu Kim, Hanbin Kim, Sang-Hyun Choi, Dong-Hoon Kim, Myunghwan Choi, Inhee Mook-Jung, Yong Taek Jeong, Obin Kwon

Abstract read
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In one paragraph

Article in Experimental neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyun Ji KimBK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Bo Hye KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.
Dong Kyu KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.
Hanbin KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.
Sang-Hyun ChoiDepartment of Pharmacology, Korea University College of Medicine, Seoul 02841, Korea.
Dong-Hoon KimBK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Myunghwan ChoiSchool of Biological Sciences, Seoul National University, Seoul 08826, Korea.
Inhee Mook-JungDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.
Yong Taek JeongBK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Obin KwonDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous systemic diseases manifest with oral symptoms and signs. The molecular diagnosis of Alzheimer's disease (AD), the most prevalent neurodegenerative disease worldwide, currently relies on invasive or expensive methods, emphasizing the imperative for easily accessible biomarkers. In this study, we explored the expression patterns of key proteins implicated in AD pathophysiology within the taste buds of mice. We detected the expression of amyloid precursor protein (APP) and tau protein in the taste buds of normal C57BL/6 mice. Phosphorylated tau was predominantly found in type II and III taste cells, while APP was located in type I taste cells. Remarkably, we observed significantly stronger immunoreactivity to phosphorylated tau in the taste buds of aged AD mouse models compared to age-matched controls. These findings underscore the oral expression of biomarkers associated with AD, highlighting the diagnostic potential of the oral cavity for neurodegenerative diseases.

Indexed as

Alzheimer’s diseaseAmyloid protein precursorImmunohistochemistryTaste budsTauopathies

Identifiers

PMID39266476
PMCPMC11411091

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