Evidence map›Paper›PMID 39266472›Full record

ArticleJournal of veterinary internal medicine

Effects of fecal microbiota transplantation on clinical outcomes and fecal microbiota of foals with diarrhea.

Jillian Bell, Sharanne L Radial, Rosemary S Cuming, Gareth Trope, Kristopher J Hughes

Abstract read
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Impact of fecal microbiota transplantation in dogs.Frontiers in veterinary science · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jillian BellCharles Sturt University School of Agricultural, Environmental and Veterinary Sciences, Wagga Wagga, New South Wales, Australia.ORCID https://orcid.org/0009-0009-9417-4864
Sharanne L RadialCharles Sturt University School of Agricultural, Environmental and Veterinary Sciences, Wagga Wagga, New South Wales, Australia.ORCID https://orcid.org/0000-0001-5558-3133
Rosemary S CumingScone Equine Hospital, Scone, New South Wales, Australia.
Gareth TropeSouth Eastern Equine Hospital, Narre Warren North, Victoria, Australia.
Kristopher J HughesCharles Sturt University School of Agricultural, Environmental and Veterinary Sciences, Wagga Wagga, New South Wales, Australia.

Funding

Agrifutures Australia
6 · The paper itself

Abstract

backgroundDiarrhea in foals can be associated with disruption of the intestinal microbiota (dysbiosis). Effective management of intestinal dysbiosis in foals has not been demonstrated. HYPOTHESIS/

objectivesFecal microbiota transplantation (FMT) in foals with diarrhea influences the intestinal microbiota and improves clinical and clinicopathological outcomes. ANIMALS: Twenty-five foals <6 months of age with diarrhea and systemic inflammatory response syndrome at 3 veterinary hospitals.

methodsA prospective randomized placebo-controlled cohort study. Foals in the FMT group (n = 19) or control group (n = 9) received FMT or electrolyte solution once daily for 3 days. Fecal samples were obtained on Day 0 (D0), D1, D2, D3, and D7. Within group and between group data analyses were performed for clinical, clinicopathological, and microbiota variables.

resultsTreatment had no effect on survival (FMT 79%; control 100%, P = .3) or resolution of diarrhea (FMT 68%; control 55%, P = .4). On D3, the white blood cell count of the FMT group was lower than the control group (D3 FMT group median 6.4 g/L [5-8.3 g/L]; D3 control group median 14.3 g/L [6.7-18.9 g/L] P = .04). Heart rate reduced over time in the FMT group (D0 median 80 bpm [60-150 bpm]; D2 median 70 bpm [52-110 bpm] [P = .005]; and D3 median 64, [54-102 bpm] [P < .001]). Phylum Verrucomicrobiota, genus Akkermansia, and family Prevotellaceae were enriched in the FMT group on D1 (linear discriminate analysis > 4). CONCLUSIONS AND CLINICAL IMPORTANCE: In foals with diarrhea, FMT appears safe and can be associated with some clinical and microbiota changes suggestive of beneficial effect.

Indexed as

DiarrheaFecal Microbiota TransplantationFecesHorse DiseasesAnimalsAnimals, NewbornCohort StudiesDysbiosisFemaleGastrointestinal MicrobiomeHorsesMaleProspective StudiesTreatment Outcomefoalnext‐generation sequencingtransplant

Identifiers

PMID39266472
PMCPMC11423448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.