Evidence map›Paper›PMID 39266455›Full record

ArticleJournal of obesity & metabolic syndrome2024

Relationships of Thickness of Perirenal Fat with Urinary Levels of MCP-1 and NGAL in Patients with Hypertension.

Anna Bragina, Yulia Rodionova, Konstantin Osadchiy, Daria Bayutina, Maria K Vasilchenko, Alexander Fomin, Valeriy Podzolkov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of obesity & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna BraginaDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Yulia RodionovaDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Konstantin OsadchiyDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Daria BayutinaDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Maria K VasilchenkoDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.ORCID https://orcid.org/0000-0002-4831-7977
Alexander FominDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Valeriy PodzolkovDepartment of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We conducted a study to determine the relationships between perirenal fat (PRF) thickness and urinary levels of monocyte chemoattractant protein-1 (MCP-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with hypertension (HTN). Methods: In 338 HTN patients (aged 63.5±12.3 years on average), MCP-1 and NGAL levels were studied using enzyme-linked immunosorbent assay (ELISA). To measure PRF thickness, all patients underwent CT scans. Results: We considered PRF thickness ≥1.91 cm as the diagnostic threshold for perirenal obesity. Patients with excessive PRF thickness exhibited significantly lower levels of MCP-1 and NGAL compared with those with PRF thickness ≥1.91 cm: 0.98 pg/mL (interquartile range [IQR], 0.21 to 2.05) vs. 2.35 pg/mL (IQR, 0.37 to 5.22) for MCP-1 and 50.0 pg/mL (IQR, 48.9 to 67.8) vs. 98.3 pg/mL (IQR, 68.4 to 187.1) for NGAL. We found a relationship of PRF thickness with both MCP-1 (r=0.46, Conclusion: We identified higher concentrations of renal fibrosis markers in patients with perirenal and MUO as well as a link between PRF thickness and MCP-1 and NGAL levels in urine.

Indexed as

Ectopic obesityFibrosisHypertensionKidneyMetabolically benign obesityPerirenal fatPerirenal fat thickness

Identifiers

PMID39266455
PMCPMC11704222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.