Evidence map›Paper›PMID 39266288›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Optimizing the Therapeutic Index of sdAb-Based Radiopharmaceuticals Using Pretargeting.

Sophie Poty, Laura Ordas, Yana Dekempeneer, Ali Asghar Parach, Laurent Navarro, Francis Santens, Nina Dumauthioz, Manuel Bardiès, Tony Lahoutte, Matthias D'Huyvetter and 1 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Comparative theranostic efficacy ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sophie PotyInstitut de Recherche en Cancérologie de Montpellier, Université de Montpellier, INSERM, U1194, Équipe labellisée Ligue contre le cancer, Montpellier, France; and sophie.poty@u-bourgogne.fr jean-pierre.pouget@inserm.fr.
Laura OrdasInstitut de Recherche en Cancérologie de Montpellier, Université de Montpellier, INSERM, U1194, Équipe labellisée Ligue contre le cancer, Montpellier, France; and.
Yana DekempeneerPrecirix NV/SA, Brussels, Belgium.
Ali Asghar ParachInstitut de Recherche en Cancérologie de Montpellier, Université de Montpellier, INSERM, U1194, Équipe labellisée Ligue contre le cancer, Montpellier, France; and.
Laurent NavarroPrecirix NV/SA, Brussels, Belgium.
Francis SantensPrecirix NV/SA, Brussels, Belgium.
Nina DumauthiozPrecirix NV/SA, Brussels, Belgium.
Manuel BardièsInstitut de Recherche en Cancérologie de Montpellier, Université de Montpellier, INSERM, U1194, Équipe labellisée Ligue contre le cancer, Montpellier, France; and.
Tony LahouttePrecirix NV/SA, Brussels, Belgium.
Matthias D'HuyvetterPrecirix NV/SA, Brussels, Belgium.
Jean-Pierre PougetInstitut de Recherche en Cancérologie de Montpellier, Université de Montpellier, INSERM, U1194, Équipe labellisée Ligue contre le cancer, Montpellier, France; and sophie.poty@u-bourgogne.fr jean-pierre.pouget@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-domain antibodies (sdAbs) demonstrate favorable pharmacokinetic profiles for molecular imaging applications. However, their renal excretion and retention are obstacles for applications in targeted radionuclide therapy (TRT).

Indexed as

RadiopharmaceuticalsSingle-Domain AntibodiesAnimalsCarcinoma, Pancreatic DuctalCell Line, TumorEndopeptidasesFemaleFibroblast Activation Protein AlphaHumansKidneyMembrane ProteinsMicePancreatic NeoplasmsTissue DistributionEndopeptidasesFibroblast Activation Protein AlphaMembrane ProteinsRadiopharmaceuticalsSingle-Domain AntibodiesFAPpretargetingsingle-domain antibody

Identifiers

PMID39266288
PMCPMC11448608

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.