ArticleJournal of medicinal chemistry2024
CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes.
Samkeliso Dlamini, Shahrzad Mohajeri, Nishanth Kuganesan, Shaimaa H Sindi, Endri Karaj, Dewmi S Rathnayake, Jade McDaniel, William R Taylor, L M Viranga Tillekeratne
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Samkeliso DlaminiDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.
Shahrzad MohajeriDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.
Nishanth KuganesanDepartment of Biological Sciences, College of Natural Sciences and Mathematics, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.
Shaimaa H SindiDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.ORCID 0000-0003-4319-0441 Endri KarajDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.ORCID 0000-0002-2393-9278 Dewmi S RathnayakeDepartment of Biological Sciences, College of Natural Sciences and Mathematics, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.
Jade McDanielDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.ORCID 0000-0002-0664-8268 William R TaylorDepartment of Biological Sciences, College of Natural Sciences and Mathematics, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.
L M Viranga TillekeratneDepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 2801, W. Bancroft Street, Toledo, Ohio 43606, United States.ORCID 0000-0002-8326-564X Funding
Regulation of Ferroptosis by the p53/CDK/Rb Axis.R15GM141712 · NIGMS · UNIVERSITY OF TOLEDO · PI TAYLOR, WILLIAM R. · 2021 to 2022
$464kNovel Small Molecule Ferroptotic Compounds to Target Mesenchymal Breast Cancer and Breast Cancer Stem CellsR15CA213185 · NCI · UNIVERSITY OF TOLEDO · PI TILLEKERATNE, VIRANGA · 2018 to 2018
$449kRegulation of the Mitotic Checkpoint by Gsk3R15GM120712 · NIGMS · UNIVERSITY OF TOLEDO · PI TAYLOR, WILLIAM R. · 2017 to 2017
$443kNCI NIH HHS R15 CA213185NIGMS NIH HHS R15 GM120712NIGMS NIH HHS R15 GM141712
6 · The paper itselfAbstract
Ferroptosis is a recently discovered cell death mechanism triggered by iron-dependent elevation of reactive oxygen species leading to lipid membrane peroxidation. We previously reported the development of a new class of ferroptosis inducers referred to as CETZOLEs with CC
Indexed as
FerroptosisAntineoplastic AgentsCell Line, TumorHumansMolecular ProbesReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsMolecular ProbesReactive Oxygen Species
Identifiers
PMID39264826
PMCPMC12338762
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