Evidence map›Paper›PMID 39264566›Full record

ArticleBulletin of experimental biology and medicine2024

Effect of Polysaccharides Isolated from Saussurea salicifolia (L.) DC on Th2-Dependent Immune Response.

A A Ligacheva, M G Danilets, E I Gulina, N S Selivanova, E S Trofimova, E Yu Sherstoboev, E Yu Avdeeva, Ya E Reshetov, S V Krivoshchekov, V V Zhdanov and 1 more

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A A LigachevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M G DaniletsGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
E I GulinaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
N S SelivanovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
E S TrofimovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. trofimova_es@pharmso.ru.
E Yu SherstoboevSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
E Yu AvdeevaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Ya E ReshetovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
S V KrivoshchekovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
V V ZhdanovGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M V BelousovSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of polysaccharides isolated from the aboveground parts of Saussurea salicifolia (L.) DC on Th2 type immune response reactions was studied. Administration of water-soluble polysaccharides presented by arabino-galacturonans (weight average molecular weight 158.49 kDa) to mice against the background of experimental Th2 immunity reduced the severity of anaphylactic and local immediate type hypersensitivity reactions. It also suppressed the production of ovalbumin-specific IgE and IgG1 and increased the stability of mast cell membranes. The studied polysaccharide complex increased IFNγ secretion and inhibited IL-4 synthesis. These findings suggest that these polysaccharides may be considered as potential anti-allergic agents that suppress the development of allergy in its early stages.

Indexed as

Immunoglobulin EPolysaccharidesSaussureaTh2 CellsAnaphylaxisAnimalsAnti-Allergic AgentsFemaleImmunoglobulin GInterferon-gammaInterleukin-4Mast CellsMiceMice, Inbred BALB COvalbuminPlant ExtractsAnti-Allergic AgentsImmunoglobulin EImmunoglobulin GInterferon-gammaInterleukin-4OvalbuminPlant ExtractsPolysaccharidesanaphylaxisIgG1 and IgEmast cell degranulationSaussurea salicifolia (L.) DCwater-soluble polysaccharides

Identifiers

PMID39264566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.