Evidence map›Paper›PMID 39264493›Full record

Observational studyInternational urology and nephrology2025

Soluble suppression of tumorigenicity 2 associated with contrast-induced acute kidney injury in patients with STEMI.

Ziyun Luo, Yong Li, Minjuan Xie, Song Yi, Shizhang Xu, Jun Luo

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ziyun Luo *Department of Nephrology, Yichun People's Hospital, Yichun, 336000, Jiangxi, China.
Yong Li *Department of Cardiology, The First People's Hospital of Yuhang District, Hangzhou, 311100, Zhejiang, China.
Minjuan XieDepartment of Medicine, Yichun University, Yichun, 336000, Jiangxi, China.
Song YiDepartment of Cardiology, Yichun People's Hospital, Yichun, 336000, Jiangxi, China.
Shizhang XuDepartment of Nephrology, Yichun People's Hospital, Yichun, 336000, Jiangxi, China.
Jun LuoDepartment of Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China. ljhk0629@163.com.

Funding

Medical and Health Technology Project of Hangzhou B20231533
6 · The paper itself

Abstract

backgroundContrast-induced acute kidney injury (CI-AKI) is a common complication after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Soluble suppression of tumorigenicity 2 (sST2) is associated with AKI. However, the relationship between sST2 and CI-AKI is unclear. This study aimed to investigate the relationship between sST2 and CI-AKI in patients with STEMI.

methodsThis was a single-center retrospective observational study. Patients diagnosed with STEMI in the Yichun People's Hospital from February 2020 to May 2024 were continuously included. CI-AKI was defined as an increase in serum creatinine of at least 50% or 0.3 mg/dL from baseline within 48-72 h after contrast exposure.

resultsThe incidence of CI-AKI after PCI was 12.4% (98/791). Univariate analysis showed that age, fasting plasma glucose, diabetes mellitus, Killip class, left ventricular ejection fraction, estimated glomerular filtration rate, high sensitivity troponin T, N-terminal pro-B-type natriuretic peptide, and sST2 were associated with CI-AKI. The above factors were included in a multivariate analysis, which showed that sST2 was an independent factor for CI-AKI after PCI. The restricted cubic splines showed a nonlinear dose-response relationship between sST2 and CI-AKI (P < 0.001). The integration of the sST2 could significantly improve the ability of the model to identify CI-AKI (NRI 0.681, 95% CI 0.474-0.887; IDI 0.063, 95% CI 0.038-0.099).

conclusionElevated sST2 is an independent risk factor for CI-AKI after PCI in patients with STEMI. Integration of sST2 can significantly improve the risk model for CI-AKI.

Indexed as

Acute Kidney InjuryContrast MediaInterleukin-1 Receptor-Like 1 ProteinPercutaneous Coronary InterventionST Elevation Myocardial InfarctionAgedFemaleHumansMaleMiddle AgedRetrospective StudiesContrast MediaIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinContrast-induced acute kidney injuryMyocardial infarctionPercutaneous coronary interventionSoluble suppression of tumorigenicity 2

Identifiers

PMID39264493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.