Evidence map›Paper›PMID 39264474›Full record

ArticleDiscover nano2024

Delivery of PAMAM dendrimers and dendriplexes across natural barriers (blood-brain barrier and placental barrier) in healthy pregnant mice.

Eric Kuhn, Bhairavi Srinageshwar, Darren T Story, Douglas Swanson, Ajit Sharma, Gary L Dunbar, Julien Rossignol

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric KuhnCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Bhairavi SrinageshwarCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Darren T StoryProgram in Neuroscience, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Douglas SwansonDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Ajit SharmaDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Gary L DunbarCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Julien RossignolCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA. rossi1j@cmich.edu.

Funding

Non-Invasive Nanoparticle Platform for Tool Delivery to the BrainR21EY030012 · NEI · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, ROSSIGNOL, JULIEN · 2019 to 2019
$520k
NEI NIH HHS R21 EY030012NIH HHS 1R21EY030012-01
6 · The paper itself

Abstract

Gene therapy is an important tool for treating fetal diseases that allows for the delivery and integration of therapeutic genes into the genome of cells carrying mutations. Nanomolecules, like PAMAM dendrimers, have recently come into wider use for carrying vectors as they have several advantages over viral vectors. Namely, (1) tunable size and surface chemistry, (2) uniform size, (3) the ability to target specific tissues, and (4) the ability to carry large biomolecules and drugs. Recently, we demonstrated that 4th generation (G4) PAMAM dendrimer with a cystamine core and a non-toxic surface having 90% -OH and 10% -NH

Indexed as

Blood brain barrierFetal medicinePAMAM dendrimersPlacental barrierPregnancy

Identifiers

PMID39264474
PMCPMC11393257

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.