Evidence map›Paper›PMID 39264441›Full record

SynthesisJournal of neurology2024

Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review.

Micaela Mitolo, Gemma Lombardi, Riccardo Manca, Benedetta Nacmias, Annalena Venneri

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Article
  12. Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Micaela Mitolo *Department of Medicine and Surgery, University of Parma, Parma, Italy.
Gemma Lombardi *Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Riccardo MancaDepartment of Medicine and Surgery, University of Parma, Parma, Italy. riccardo.manca@brunel.ac.uk.ORCID http://orcid.org/0000-0003-1715-6442
Benedetta Nacmias *Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Annalena Venneri *Department of Medicine and Surgery, University of Parma, Parma, Italy.

Funding

Ministero dell'Università e della Ricerca PE0000006
6 · The paper itself

Abstract

Blood-based biomarkers (BBM) are becoming easily detectable tools to reveal pathological changes in Alzheimer's disease (AD). A comprehensive and up-to-date overview of the association between BBM and brain MRI parameters is not available. This systematic review aimed to summarize the literature on the associations between the main BBM and MRI markers across the clinical AD continuum. A systematic literature search was carried out on PubMed and Web of Science and a total of 33 articles were included. Hippocampal volume was positively correlated with Aβ42 and Aβ42/Aβ40 and negatively with Aβ40 plasma levels. P-tau181 and p-tau217 concentrations were negatively correlated with temporal grey matter volume and cortical thickness. NfL levels were negatively correlated with white matter microstructural integrity, whereas GFAP levels were positively correlated with myo-inositol values in the posterior cingulate cortex/precuneus. These findings highlight consistent associations between various BBM and brain MRI markers even in the pre-clinical and prodromal stages of AD. This suggests a possible advantage in combining multiple AD-related markers to improve accuracy of early diagnosis, prognosis, progression monitoring and treatment response.

Indexed as

Alzheimer DiseaseBiomarkersBrainMagnetic Resonance ImagingAmyloid beta-PeptidesHumanstau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer’s diseaseBlood-based biomarkersDementiaMild cognitive impairmentMRISubjective cognitive decline

Identifiers

PMID39264441
PMCPMC11560990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.