Evidence map›Paper›PMID 39264428›Full record

Observational studyEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2024

Epidemiology of postinjury multiple organ failure: a prospective multicenter observational study.

Ryan S Ting, Natasha A Weaver, Kate L King, Teagan L Way, Pooria Sarrami, Lovana Daniel, Michael Dinh, Priya Nair, Jeremy Hsu, Scott K D'Amours and 1 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Artificial intelligence-driven clustering for phenotyping life-threatening prehospital trauma.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryan S TingSt George & Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0003-0106-3129
Natasha A WeaverUniversity of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0002-9640-1647
Kate L KingJohn Hunter Hospital, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia.
Teagan L WayJohn Hunter Hospital, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0002-4341-2879
Pooria SarramiNSW Institute of Trauma and Injury Management, NSW Agency for Clinical Innovation and University of New South Wales, South West Sydney Clinical School, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-4034-1059
Lovana DanielWestmead Hospital, University of New South Wales, South West Sydney Clinical School, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0003-1241-6567
Michael DinhNSW Institute of Trauma and Injury Management, NSW Agency for Clinical Innovation and University of New South Wales, South West Sydney Clinical School, Sydney, NSW, Australia.
Priya NairSt Vincent's Hospital, Sydney, Australia.
Jeremy HsuWestmead Hospital, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-7324-8088
Scott K D'AmoursLiverpool Hospital Trauma and Acute Care Surgery Unit, University of New South Wales, South West Sydney Clinical School, Sydney, NSW, Australia.ORCID https://orcid.org/0009-0004-4975-7984
Zsolt J BaloghJohn Hunter Hospital, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia. zsolt.balogh@health.nsw.gov.au.ORCID https://orcid.org/0000-0002-0277-4822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostinjury multiple organ failure (MOF) is the sequela to the disease of polytrauma. We aimed to describe the contemporary population-based epidemiology of MOF within a mature trauma system, to analyse the time taken for MOF to develop, and to evaluate the temporal patterns and contributions of the individual constituent organ failures.

methodsProspective observational study conducted across five Level-1 trauma centers in New South Wales, Australia. Trauma patients at-risk of MOF (Denver > 3 from 48 h post-admission), aged > 16 years, ISS > 15, and who stayed in ICU for ≥ 48 h were eligible for inclusion.

resultsFrom May 2018-February 2021, 600 at-risk polytrauma patients were prospectively enrolled (mean(SD)age = 49(21)years, males = 453/600(76%),median(IQR)ISS = 26(20,34)). MOF incidence was 136/600(23%) among at-risk patients, 142/6248(2%) among major trauma patients (ISS > 12 per Australian definition), and 0.8/100,000 in the general population. The mortality rate was 55/600(11%) in the overall study population, and 34/136(25%) in MOF patients. 82/136(60%) of MOF patients developed MOF on day-3. No patients developed MOF after day-13. Among MOF patients, 60/136(44%) had cardiac failures (mortality = 37%), 39/136(29%) had respiratory failures (mortality = 23%), 24/136(18%) had renal failures (mortality = 63%), and 12/136(9%) had hepatic failures (mortality = 50%).

conclusionAlthough a rare syndrome in the general population, MOF occurred in 23% of the most severely injured polytrauma patients. When compared to previous risk-matched cohorts, MOF become more common, but not more lethal, despite a decade older cohort. The heart has superseded the lungs as the most common organ to fail. Cardiac and respiratory failures occurred earlier and were associated with lower mortality than renal and hepatic failures.

Indexed as

Multiple Organ FailureMultiple TraumaAdultAgedFemaleHumansIncidenceInjury Severity ScoreMaleMiddle AgedNew South WalesProspective StudiesRisk FactorsTrauma CentersEpidemiologyMultiple organ failurePolytraumaTraumaTrauma Center

Identifiers

PMID39264428
PMCPMC11666632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.