Evidence map›Paper›PMID 39264311›Full record

ArticleJournal of chemical information and modeling2024

Small Molecule NS11021 Promotes BK Channel Activation by Increasing Inner Pore Hydration.

Erik B Nordquist, Zhiguang Jia, Jianhan Chen

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erik B NordquistDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.ORCID 0000-0001-9139-0152
Zhiguang JiaDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Jianhan ChenDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.ORCID 0000-0002-5281-1150

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Disordered Proteins and Dynamic Interactions in Biology and Diseases.R35GM144045 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jianhan Chen · 2022 to 2026
$2.0M
BLOOD-BRAIN BARRIER INDUCTION BY GLIA AND STEROIDSF32NS011021 · NINDS · UNIVERSITY OF WASHINGTON · PI GRANT, GERALD A · 2000 to 2001
$90k
NIGMS NIH HHS R35 GM144045NIGMS NIH HHS T32 GM139789NINDS NIH HHS F32 NS011021
6 · The paper itself

Abstract

The Ca

Indexed as

Large-Conductance Calcium-Activated Potassium ChannelsMolecular Dynamics SimulationWaterHumansHydrophobic and Hydrophilic InteractionsIon Channel GatingProtein BindingProtein ConformationTetrazolesThermodynamicsThiourea1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thioureaLarge-Conductance Calcium-Activated Potassium ChannelsTetrazolesThioureaWater

Identifiers

PMID39264311
PMCPMC12025341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.