Evidence map›Paper›PMID 39264305›Full record

ReviewLeukemia & lymphoma2025

Untangling the loops of

Varun S Sudunagunta, Aaron D Viny

Abstract readReview
In one paragraph

Review in Leukemia & lymphoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Varun S SudunaguntaColumbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-8639-8907
Aaron D VinyColumbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0001-7039-0110

Funding

The role of the cohesin complex in hematopoietic transformation and leukemia maintenanceR37CA286857 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AARON D VINY · 2023 to 2026
$2.5M
NCI NIH HHS R37 CA286857
6 · The paper itself

Abstract

Myelodysplastic syndrome (MDS) is a heterogeneous myeloid neoplasm that is hallmarked by the acquisition of genetic events that disrupt normal trilineage hematopoiesis and results in bone marrow dysfunction. Somatic genes involving transcriptional regulation, signal transduction, DNA methylation, and chromatin modification are often implicated in disease pathogenesis. The cohesin complex, composed of SMC1, SMC3, RAD21, and either STAG1 or STAG2, has been identified as a recurrent mutational target with

Indexed as

Cell Cycle ProteinsCohesinsMutationMyelodysplastic SyndromesAntigens, NuclearChromosomal Proteins, Non-HistoneGenetic Predisposition to DiseaseHumansPrognosisAntigens, NuclearCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsSTAG2 protein, humancohesinMDSmyeloid malignancySTAG2

Identifiers

PMID39264305
PMCPMC11695156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.