Evidence map›Paper›PMID 39264272›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Enhancing Cardioprotection Through Neutrophil-Mediated Delivery of 18β-Glycyrrhetinic Acid in Myocardial Ischemia/Reperfusion Injury.

Dongjian Han, Fuhang Wang, Qingjiao Jiang, Zhentao Qiao, Yuansong Zhuang, Quanxu An, Yuhang Li, Yazhe Tang, Chenyao Li, Deliang Shen

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dongjian HanDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.ORCID 0000-0002-0236-8410
Fuhang WangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Qingjiao JiangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhentao QiaoDepartment of Vascular and Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yuansong ZhuangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Quanxu AnDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yuhang LiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yazhe TangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chenyao LiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Deliang ShenDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.ORCID 0000-0002-1826-5141

Funding

Henan key research and development projects 241111311600National Natural Science Foundation of China 81873493National Natural Science Foundation of China 82170271
6 · The paper itself

Abstract

Myocardial ischemia/reperfusion injury (MI/RI) generates reactive oxygen species (ROS) and initiates inflammatory responses. Traditional therapies targeting specific cytokines or ROS often prove inadequate. An innovative drug delivery system (DDS) is developed using neutrophil decoys (NDs) that encapsulate 18β-glycyrrhetinic acid (GA) within a hydrolyzable oxalate polymer (HOP) and neutrophil membrane vesicles (NMVs). These NDs are responsive to hydrogen peroxide (H

Indexed as

Disease Models, AnimalGlycyrrhetinic AcidMyocardial Reperfusion InjuryNeutrophilsAnimalsCardiotonic AgentsDrug Delivery SystemsHumansMaleMiceRatsReactive Oxygen Species18alpha-glycyrrhetinic acidCardiotonic AgentsGlycyrrhetinic AcidReactive Oxygen Speciesdrug deliveryinflammationmyocardial ischemia‐reperfusion injurynanomedicineneutrophil decoys (NDs)reactive oxygen species (ROS)

Identifiers

PMID39264272
PMCPMC11558124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.