Evidence map›Paper›PMID 39264028›Full record

Observational studyNeurourology and urodynamics2024

Reliability of Uroflowmetry Pattern Interpretation in Adult Women.

Leslie M Rickey, Elizabeth R Mueller, Diane K Newman, Alayne D Markland, Chloe Falke, Kyle Rudser, Ariana L Smith, Margaret G Mueller, Jerry L Lowder, Emily S Lukacz and 1 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Neurourology and urodynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04016298 (Validation of Bladder Health Instrument for Evaluation in Women), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04016298 completednot on this map

Validation of Bladder Health Instrument for Evaluation in Women

TypeobservationalSponsorUniversity of MinnesotaRan2019 to 2022Enrolled1,222ConditionsLower Urinary Tract Symptoms
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leslie M RickeyDepartment of Urology & Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-1306-8982
Elizabeth R MuellerDepartment of Obstetrics and Gynecology, Loyola University Chicago, Chicago, Illinois, USA.
Diane K NewmanDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alayne D MarklandDepartment of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-6567-6744
Chloe FalkeDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Kyle RudserDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Ariana L SmithDivision of Urology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9784-2559
Margaret G MuellerDepartment of Obstetrics and Gynecology, University of Chicago Medicine, Chicago, Illinois, USA.
Jerry L LowderDepartment of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1065-4537
Emily S LukaczDivision of Female Pelvic Medicine & Reconstructive Surgery, UC San Diego, San Diego, California, USA.
Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium

Funding

Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating CenterU24DK106786 · NIDDK · UNIVERSITY OF MINNESOTA · PI MCGWIN, GERALD, RUDSER, KYLE · 2020 to 2024
$7.1M
University of Pennsylvania+ PLUS Clinical Center (PENN+PLUS CC)U01DK106892 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NEWMAN, DIANE K., SMITH, ARIANA L · 2015 to 2024
$5.4M
PLUS Loyola Clinical CenterU01DK106898 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA, FITZGERALD, COLLEEN MARIE · 2015 to 2024
$4.7M
Prevention of LUTS: Bladder Health Clinical Center, UC San Diego SiteU01DK106827 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACOURSIERE, DAPHNE YVETTE, LUKACZ, EMILY S. · 2015 to 2024
$4.5M
Pathways to LUTS Prevention: A Model for Public Education, Behavioral Skills, and Early DetectionU01DK106858 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCGWIN, GERALD · 2015 to 2024
$4.5M
LUTS PREVENTION IN ADOLESCENT GIRLS AND WOMEN ACROSS THE LIFESPANU01DK106853 · NIDDK · WASHINGTON UNIVERSITY · PI SUTCLIFFE, SIOBHAN · 2015 to 2024
$4.0M
The Truly Healthy Bladder: Understanding Normal As A Pathway To Prevention Of Lower Urinary Tract Symptoms In WomenU01DK106893 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, LISA KANE · 2015 to 2024
$3.8M
Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Yale Clinical Research CenterU01DK106908 · NIDDK · YALE UNIVERSITY · PI RICKEY, LESLIE M. · 2015 to 2024
$3.5M
NORTHWESTERN UNIVERSITY PLUS CLINICAL SITEU01DK126045 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRIFFITH, JAMES WILLIAM, SIMON, MELISSA A. · 2020 to 2024
$1.4M
NIDDK NIH HHS U01 DK106827NIDDK NIH HHS U01 DK106853NIDDK NIH HHS U01 DK106858NIDDK NIH HHS U01 DK106892NIDDK NIH HHS U01 DK106893NIDDK NIH HHS U01 DK106898NIDDK NIH HHS U01 DK106908NIDDK NIH HHS U01 DK126045NIDDK NIH HHS U24 DK106786This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH) by cooperative agreements [grants U24DK106786, U01 DK106853, U01 DK106858, U01 DK106898, U01 DK106893, U01 DK106827, U01 DK106908, U01 DK106892, U01 DK126045].
6 · The paper itself

Abstract

introductionUroflowmetry is often used to assess lower urinary tract symptoms (LUTS). Criteria for characterization of flow patterns are not well established, and subjective interpretation is the most common approach for flow curve classification. We assessed the reliability of uroflowmetry curve interpretation in adult women. MATERIALS AND

methodsUroflowmetry studies were obtained in 296 women who participated in an observational cohort study. Four investigators with expertise in female LUTS and urodynamics reviewed and categorized each tracing for interrater reliability. A random subset of 50 tracings was re-reviewed by each investigator for intrarater reliability. The uroflowmetry tracings were rated using categories of continuous, continuous fluctuating, interrupted, and prolonged. Other parameters included flow rate, voided volume, time to maximum flow, and voiding time. Agreement between raters is summarized with kappa (k) statistics and percentage where at least three raters agreed.

resultsThe mean age of participants was 44.8 ± 18.3 years. Participant age categories were 18-24 years: 20%; 25-34 years: 17%; 35-64 years: 42%; 65+ years: 18%. Nine percent described their race as Asian, 31% Black, 62% White, and 89% were of non-Hispanic ethnicity. The interrater reliability was highest for the continuous flow category (k = 0.65), 0.47 for prolonged, 0.41 for continuous fluctuating, and 0.39 for interrupted flow curves. Agreement among at least three raters occurred in 74.3% of uroflow curves (69% for continuous, 33% for continuous fluctuating, 23% for interrupted, and 25% for prolonged). For intrarater reliability, the mean k was 0.72 with a range of 0.57-0.85.

conclusionsCurrently accepted uroflowmetry pattern categories have fair to moderate interrater reliability, which is lower for flow curves that do not meet "continuous" criteria. Given the subjective nature of interpreting uroflowmetry data, more consistent and clear parameters may enhance reliability for use in research and as a screening tool for LUTS and voiding dysfunction.

trial registrationParent trial: Validation of Bladder Health Instrument for Evaluation in Women (VIEW); ClinicalTrials.gov ID: NCT04016298.

Indexed as

RheologyUrodynamicsAdolescentAdultAgedFemaleHumansLower Urinary Tract SymptomsMiddle AgedObserver VariationReproducibility of ResultsUrinary BladderUrinationYoung Adultfemale urogenital diseasephysiologyreliability and validityurinary tracturodynamicsvoiding dysfunction

Identifiers

PMID39264028
PMCPMC12006900

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.