Evidence map›Paper›PMID 39263969›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies.

Roxane Dilcher, Stephan Wall, Mattes Groß, Sabrina Katzdobler, Olivia Wagemann, Carla Palleis, Endy Weidinger, Urban Fietzek, Alexander Bernhardt, Carolin Kurz and 20 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Dynamic [Molecular neurodegeneration · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  6. Comorbid pathologies and their impact on progressive supranuclear palsy: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Developing a novel reference region for [European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Exploring the origins of frequent tau-PET signal in vermal and adjacent regions.European journal of nuclear medicine and molecular imaging · 2025
    Article
  12. Early-phaseEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Roxane DilcherNeuroscience, Monash University, Melbourne, Australia.ORCID 0000-0002-1307-6747
Stephan WallDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.
Mattes GroßInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, München, Germany.
Sabrina Katzdobler(SyNergy), Munich Cluster for Systems Neurology, München, Germany.
Olivia WagemannDepartment of Neurology, University Hospital of Munich, LMU Munich, München, Germany.
Carla Palleis(SyNergy), Munich Cluster for Systems Neurology, München, Germany.
Endy WeidingerDepartment of Neurology, University Hospital of Munich, LMU Munich, München, Germany.
Urban FietzekDepartment of Neurology, University Hospital of Munich, LMU Munich, München, Germany.
Alexander BernhardtDepartment of Neurology, University Hospital of Munich, LMU Munich, München, Germany.
Carolin KurzDepartment of Psychiatry and Psychotherapy, University Hospital of Munich, LMU Munich, München, Germany.
Christian FerschmannDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.
Maximilian ScheifeleDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.
Mirlind ZaganjoriDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.
Johannes GnörichDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.
Katharina BürgerInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, München, Germany.
Daniel JanowitzInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, München, Germany.
Boris-Stephan RauchmannDepartment of Psychiatry and Psychotherapy, University Hospital of Munich, LMU Munich, München, Germany.
Sophia StöckleinDepartment of Radiology, University Hospital of Munich, LMU Munich, München, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.
Victor VillemagneDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John SeibylInstitute for Neurodegenerative Disorders, New Haven, Connecticut, USA.
Osama SabriDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Henryk BarthelDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Robert Perneczky(SyNergy), Munich Cluster for Systems Neurology, München, Germany.
Florian SchöberlDepartment of Neurology, University Hospital of Munich, LMU Munich, München, Germany.
Andreas ZwergalDepartment of Neurology, University Hospital of Munich, LMU Munich, München, Germany.
Günter U Höglinger(SyNergy), Munich Cluster for Systems Neurology, München, Germany.
Johannes Levin(SyNergy), Munich Cluster for Systems Neurology, München, Germany.
Nicolai FranzmeierInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, München, Germany.ORCID 0000-0001-9736-2283
Matthias BrendelDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, München, Germany.

Funding

Deutsche Forschungsgemeinschaft (DFG) EXC2145SyNergy-ID390857198German Federal Ministry of Education and Research BMBF,01EK1605AHitTauLüneburg HeritageMonash UniversityThiemann Foundation
6 · The paper itself

Abstract

introductionRecent advances in biomarker research have improved the diagnosis and monitoring of Alzheimer's disease (AD), but in vivo biomarker-based workflows to assess 4R-tauopathy (4RT) patients are currently missing. We suggest a novel biomarker-based algorithm to characterize AD and 4RTs.

methodsWe cross-sectionally assessed combinations of cerebrospinal fluid measures (CSF p-tau

resultsElevated CSF p-tau DISCUSSION: The specific combination of CSF markers and HIGHLIGHTS: Novel biomarker-based algorithm for differentiating AD and 4R-tauopathies. A combination of CSF p-tau

Indexed as

Alzheimer DiseaseBiomarkersPositron-Emission Tomographytau ProteinsAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedTauopathiesBiomarkerstau Proteins18F‐PI‐26204‐repeat tauopathiesAlzheimer's diseasebiomarkerscerebrospinal fluidperfusionPETtau

Identifiers

PMID39263969
PMCPMC11485081

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.