Evidence map›Paper›PMID 39263842›Full record

ArticleAdvanced healthcare materials2024

Enhanced Nitric Oxide Delivery Through Self-Assembling Nanoparticles for Eradicating Gram-Negative Bacteria.

Xiangfeng Lai, Lei Yu, Xiangyi Huang, Wil Gardner, Sarah E Bamford, Paul J Pigram, Shuhong Wang, Anton P Le Brun, Benjamin W Muir, Jiangning Song and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiangfeng LaiDepartment of Materials Science and Engineering, Faculty of Engineering, Monash University, Clayton, Victoria, 3800, Australia.
Lei YuSchool of Chemistry, Monash University, Clayton, VIC, 3800, Australia.
Xiangyi HuangDepartment of Materials Science and Engineering, Faculty of Engineering, Monash University, Clayton, Victoria, 3800, Australia.
Wil GardnerCentre for Materials and Surface Science and Department of Mathematical and Physical Sciences, La Trobe University, Bundoora, 3086, Australia.
Sarah E BamfordCentre for Materials and Surface Science and Department of Mathematical and Physical Sciences, La Trobe University, Bundoora, 3086, Australia.
Paul J PigramCentre for Materials and Surface Science and Department of Mathematical and Physical Sciences, La Trobe University, Bundoora, 3086, Australia.
Shuhong WangDepartment of Materials Science and Engineering, Faculty of Engineering, Monash University, Clayton, Victoria, 3800, Australia.
Anton P Le BrunAustralian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, 2232, Australia.
Benjamin W MuirCSIRO Manufacturing, Clayton, VIC, 3168, Australia.
Jiangning SongInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, 3800, Australia.
Yajun WangCollege of Chemistry & Materials Engineering, Wenzhou University, Shanghai, Wenzhou, 325027, China.
Hsien-Yi HsuSchool of Energy and Environment & Department of Materials Science and Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.
Philip Wai Hong ChanSchool of Chemistry, Monash University, Clayton, VIC, 3800, Australia.
Hsin-Hui ShenDepartment of Materials Science and Engineering, Faculty of Engineering, Monash University, Clayton, Victoria, 3800, Australia.ORCID 0000-0002-8541-4370

Funding

Australian GovernmentAustralian Institute of Nuclear Science and Engineering Early Career Researcher grant ALNGRA2307Australian Research CouncilDiscovery Project Grant DP210103425National Health and Medical Research Council APP 2029218National Intelligence and Security Discovery Research Grant NI210100127NHMRC Career Development Research Fellowship GNT1106798
6 · The paper itself

Abstract

In the current battle against antibiotic resistance, the resilience of Gram-negative bacteria against traditional antibiotics is due not only to their protective outer membranes but also to mechanisms like efflux pumps and enzymatic degradation of drugs, underscores the urgent need for innovative antimicrobial tactics. Herein, this study presents an innovative method involving the synthesis of three furoxan derivatives engineered to self-assemble into nitric oxide (NO) donor nanoparticles (FuNPs). These FuNPs, notably supplied together with polymyxin B (PMB), achieve markedly enhanced bactericidal efficacy against a wide spectrum of bacterial phenotypes at considerably lower NO concentrations (0.1-2.8 µg mL

Indexed as

Anti-Bacterial AgentsGram-Negative BacteriaNanoparticlesNitric OxideMicrobial Sensitivity TestsPolymyxin BAnti-Bacterial AgentsNitric OxidePolymyxin Bantimicrobial resistancebacterial membraneneutronnitric oxideself‐assembly

Identifiers

PMID39263842
PMCPMC11670277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.