The effect of temperature and breathing pattern on the surface activity of ground squirrel pulmonary surfactant.

Akash Tejura, Mengxi Sun, Lynda McCaig, James Staples, Ruud Veldhuizen

Abstract read

In one paragraph

Article in The Journal of experimental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Akash TejuraDepartments of Physiology and Pharmacology, Medicine, Western University, London, ON, Canada, N6A 5C1.

Mengxi SunDepartments of Physiology and Pharmacology, Medicine, Western University, London, ON, Canada, N6A 5C1.

Lynda McCaigDepartments of Physiology and Pharmacology, Medicine, Western University, London, ON, Canada, N6A 5C1.

James StaplesDepartment of Biology, Western University, London, ON, Canada, N6A 3K7.

Ruud VeldhuizenDepartments of Physiology and Pharmacology, Medicine, Western University, London, ON, Canada, N6A 5C1.ORCID 0000-0002-8802-1580

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN 04745-2019NSERC RGPIN 04745-2019Western University

6 · The paper itself

Abstract

This study investigates how hibernation affects the surface activity of pulmonary surfactant with respect to temperature and breathing pattern. Surfactant was isolated from a hibernating species, the 13-lined ground squirrel, and a homeotherm, the rabbit, and analysed for biophysical properties on a constrained sessile drop surfactometer. The results showed that surfactant from ground squirrels reduced surface tension better at low temperatures, including when mimicking episodic breathing, as compared with rabbit surfactant. In addition, low temperature adaptation was also observed using only the hydrophobic components of surfactant from ground squirrels. Overall, the data support the conclusion that ground squirrel surfactant has adapted to maintain surface activity during low temperature episodic breathing patterns, and that temperature adaptation is maintained with the hydrophobic components of the surfactant.

Indexed as

HibernationPulmonary SurfactantsSciuridaeSurface TensionTemperatureAnimalsRabbitsRespirationPulmonary SurfactantsHibernationSurface filmSurface tension

Identifiers

PMID39263756

DOI10.1242/jeb.249280

PMCPMC11491808

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.