Evidence map›Paper›PMID 39263578›Full record

ArticleOphthalmology science

Retinal Microstructural Changes Reflecting Treatment-Associated Cognitive Dysfunction in Patients with Lower-Grade Gliomas.

Arina Nisanova, Ashutosh Parajuli, Bhavna Antony, Orwa Aboud, Jinger Sun, Megan E Daly, Ruben C Fragoso, Glenn Yiu, Yin Allison Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arina NisanovaDepartment of Ophthalmology & Vision Science, University of California Davis, Sacramento, California.
Ashutosh ParajuliInstitute of Innovation, Science & Sustainability, Federation University Australia, Ballart, Victoria, Australia.
Bhavna AntonyInstitute of Innovation, Science & Sustainability, Federation University Australia, Ballart, Victoria, Australia.
Orwa AboudDepartment of Neurological Surgery, University of California Davis, Sacramento, California.
Jinger SunDepartment of Radiation Oncology, University of California Davis, Sacramento, California.
Megan E DalyDepartment of Radiation Oncology, University of California Davis, Sacramento, California.
Ruben C FragosoDepartment of Radiation Oncology, University of California Davis, Sacramento, California.
Glenn YiuDepartment of Ophthalmology & Vision Science, University of California Davis, Sacramento, California.
Yin Allison LiuDepartment of Ophthalmology & Vision Science, University of California Davis, Sacramento, California.

Funding

Soft drusen in rhesus macaques as a nonhuman primate model of early age-related macular degenerationR01EY032238 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YIU, GLENN · 2021 to 2025
$3.2M
NEI NIH HHS R01 EY032238
6 · The paper itself

Abstract

Purpose: To determine whether microstructural retinal changes, tumor features, and Design: Cohort study. Participants and Controls: Sixteen patients with lower-grade glioma at a United States academic ophthalmology department between January 2021 and November 2023. Normal controls were recruited from convenient sampling. Methods: Montreal Cognitive Assessment (MoCA) scores and retinal changes were assessed in 6-month intervals. Main Outcome Measures: The main outcome measure was cognitive status as measured by the MoCA score and analyzed in relation to ophthalmic measurements, tumor features, and Results: Median time to first eye examination was 34 months (2-266) from tumor diagnosis and 23 months (0-246) from radiation. Nine patients (56%) had abnormal cognition (MoCA <26/30). Montreal Cognitive Assessment scores were significantly worse in patients with temporal (22 ± 7.2) than frontal lobe tumors (26 ± 3.1, Conclusions: Retinal microstructural changes may serve as biomarkers for TACD in patients with lower-grade gliomas. Temporal lobe tumors and oligodendrogliomas may increase susceptibility to TACD. Utilization of retinal markers may enhance TACD diagnosis, progression monitoring, and inform management of lower-grade patients with glioma. A larger study with serial eye examinations is warranted to evaluate the role of Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Apolipoprotein ELower-grade gliomaOphthalmic markersRetinal changesTreatment-associated cognitive dysfunction

Identifiers

PMID39263578
PMCPMC11388696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.