Comparison of lidocaine bicarbonate with fentanyl and chloroprocaine for epidural anesthesia during cesarean section: a randomized, controlled, double-blind clinical trial.

Jing Yu, Jingjing Liu, Chenran Wang, Congzhong Song, Gangming He, Chaohui Liu, Zhong Mei, Shaoqiang Huang

Abstract read

In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing Yu *Department of Anesthesia, Affiliated Zhejiang Xiaoshan Hospital of Hangzhou Normal University, Hangzhou, China.

Jingjing Liu *Department of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Chenran WangDepartment of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Congzhong SongDepartment of Anesthesia, Affiliated Zhejiang Xiaoshan Hospital of Hangzhou Normal University, Hangzhou, China.

Gangming HeDepartment of Anesthesia, Affiliated Zhejiang Xiaoshan Hospital of Hangzhou Normal University, Hangzhou, China.

Chaohui LiuDepartment of Anesthesia, Affiliated Zhejiang Xiaoshan Hospital of Hangzhou Normal University, Hangzhou, China.

Zhong MeiDepartment of Anesthesia, Affiliated Zhejiang Xiaoshan Hospital of Hangzhou Normal University, Hangzhou, China.

Shaoqiang HuangDepartment of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chloroprocaine and lidocaine bicarbonate are commonly used for epidural anesthesia because of their rapid onset, particularly in the case of conversion from epidural labor analgesia to emergency cesarean section. However, it is unclear whether lidocaine bicarbonate combined with fentanyl has an advantage over chloroprocaine alone in emergency cesarean section. In this study, 102 women who underwent elective cesarean section received 15 mL 3% chloroprocaine and 1 mL saline (CP group) or 15 mL 1.73% lidocaine bicarbonate and 1 mL fentanyl 50 μg (LF group) for epidural anesthesia. Nociceptive block level was assessed by pinprick and recorded every minute. The primary outcome was the onset time to T6 block. The median onset time to T6 analgesia was 10 [10, 10] min in the CP group and 10 [7, 10] min in the LF group (COX model for CP

Indexed as

cesarean sectionchloroprocaineepidural anesthesiafentanyllidocaine bicarbonate

Identifiers

PMID39263568

DOI10.3389/fphar.2024.1432918

PMCPMC11387887

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.