Gender-related differences in left atrial strain mechanics and exercise capacity in hypertrophic cardiomyopathy: a propensity-score matched study from the Cleveland Clinic.

Bo Xu, Yoshihito Saijo, Nicholas G Smedira, Erik Van Iterson, Maran Thamilarasan, Zoran B Popović, Milind Y Desai

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Article in Cardiovascular diagnosis and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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3 · Its place in the literature

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1 citing paper in PubMed.

Left atrial myopathy predicts cardiovascular outcome in hypertension and diabetes.The international journal of cardiovascular imaging · 2026
Article

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5 · Who and what money

Authors and funding

7 authors.

Bo Xu *Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-2985-7468

Yoshihito Saijo *Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Nicholas G SmediraDepartment of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Erik Van ItersonSection of Preventive Cardiology and Rehabilitation, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Maran ThamilarasanSection of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Zoran B PopovićSection of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Milind Y DesaiSection of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Male and female patients with hypertrophic cardiomyopathy (HCM) differ in physiologic characteristics and hemodynamics. Little is known about gender-related differences in left atrial (LA) strain and exercise capacity. The aim of this study was to assess the gender-related differences in the relationship between exercise capacity and cardiac function including LA function in patients with HCM. Methods: Five hundred and thirty-two patients with HCM undergoing exercise stress echocardiography and cardiopulmonary exercise testing (CPET) were prospectively recruited between October 2015 and April 2019 as part of a cohort study in a quaternary referral center. To reduce potential confounding factors, propensity score (PS) matching was performed in 420 patients. LA strain mechanics were evaluated using speckle-tracking echocardiography. Results: The majority of patients were male, comprising 58% of the total. Female HCM patients were older (54±14 Conclusions: Gender-related differences in LA reservoir strain were increasingly evident for older HCM patients aged 60 years and older. LA reservoir strain was an independent determinant of percent-predicted peak VO

Indexed as

cardiopulmonary exercise testing (CPET)gender-related differenceshypertrophic cardiomyopathy (HCM)Left atrial function (LA function)strain imaging

Identifiers

PMID39263484

DOI10.21037/cdt-24-147

PMCPMC11384459

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