Evidence map›Paper›PMID 39263135›Full record

ArticleHeliyon2024

The presence of spontaneous echo contrast didn't increase the risk for left atrial appendage closure: A propensity score matching analysis based on the CLACBAC study.

Jun Zhang, Lili Zhou, Zhongyuan Ren, Shiyu Feng, Jiayu Wu, Haotian Yang, Yixing Zheng, Weilun Meng, Yang Su, Jun Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Jun ZhangHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Lili ZhouHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhongyuan RenHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Shiyu FengTongji University School of Medicine, Shanghai, China.
Jiayu WuHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Haotian YangHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yixing ZhengDepartment of Cardiology, Putuo District People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Weilun MengHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yang SuHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Jun XuHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Hui SunHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yifan ZhaoHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yun XieDepartment of Cardiology, Putuo District People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yawei XuHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Dongdong ZhaoHeart Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Left atrial appendage closure (LAAC) was effective in preventing thromboembolic events and stroke in patients with atrial fibrillation (AF). However, whether left atrial spontaneous echo contrast (LA-SEC) poses a higher risk for thromboembolism is contradictory. We aimed to investigate whether LA-SEC is a risk factor for thromboembolic events in patients who underwent LAAC. Methods: 258 consecutive patients who underwent successful LAAC were enrolled and divided according to the presence or absence of LA-SEC detected by transesophageal echocardiography (TEE). Propensity score matching (PSM) was used to eliminate covariate imbalances. Baseline characteristics, periprocedural details, and clinical outcomes were compared between LA-SEC and non-LA-SEC groups and PSM-matched groups. Results: Of the 258 patients enrolled, mean age was 71.8 ± 8.3 years and 59.3 % were male. LA-SEC group had a higher percentage of persistent AF and worse cardiac function. No significant difference in peri-procedure parameters was found. Through follow-up of 38.1 ± 10.7 months, the total incidence of thromboembolic events and stroke was 7.8 % and 6.6 %, respectively. Though the event-free survival rate of thromboembolic events (Log-Rank P = 0.042) and stroke (Log-Rank P = 0.010) was significantly lower in the LA-SEC group, multivariable COX regression analysis showed LA-SEC was not an independent predictor of thromboembolic events (Hazard ratio 2.073, 95 % Confidence interval 0.845-5.082, P = 0.111). Further survival analysis between PSM-matched groups with comparable baseline characteristics presented no significant difference in survival free from thromboembolic events (Log-Rank P = 0.616) and stroke (Log-Rank P = 0.312). Conclusion: Patients with LA-SEC had worse condition, while LA-SEC per se did not increase the incidence of thromboembolic events and stroke for patients who underwent LAAC.

Indexed as

Atrial fibrillationLeft atrial appendage closureSpontaneous echo contrastThromboembolic events

Identifiers

PMID39263135
PMCPMC11387375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.