Evidence map›Paper›PMID 39262976›Full record

ArticleHeliyon2024

T lymphocyte-derived IFN-γ facilitates breast cancer cells to pass the blood-brain barrier: An

Rute M S M Pedrosa, Johan M Kros, Benjamin Schrijver, Cor Berrevoets, Rute B Marques, Casper C H J van Eijck, Reno Debets, PieterJ M Leenen, Willem A Dik, DanaA M Mustafa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rute M S M PedrosaDepartment of Pathology, The Tumor Immuno-Pathology Laboratory, Erasmus University Medical Center, Rotterdam, the Netherlands.
Johan M KrosDepartment of Pathology, The Tumor Immuno-Pathology Laboratory, Erasmus University Medical Center, Rotterdam, the Netherlands.
Benjamin SchrijverDepartment of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Cor BerrevoetsDepartment of Medical Oncology, Laboratory of Tumor Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Rute B MarquesDepartment of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Casper C H J van EijckDepartment of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
Reno DebetsDepartment of Medical Oncology, Laboratory of Tumor Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
PieterJ M LeenenDepartment of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Willem A DikDepartment of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
DanaA M MustafaDepartment of Pathology, The Tumor Immuno-Pathology Laboratory, Erasmus University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The appearance of brain metastasis is the most serious complication of breast cancer with mostly fatal outcomes. To reach the brain, tumor cells need to pass the blood-brain barrier (BBB). The molecular mechanisms underlying penetration of the BBB are largely unknown. Previously we found that tumor-infiltrating T lymphocytes enhance the development of brain metastasis of estrogen receptor-negative (ER-) breast cancer. In the current study, we investigate the contribution of T lymphocytes and the IFN-γ pathway in enabling breast cancer cells to pass the

Indexed as

Blood-brain barrierBrainBreast cancerImmune responseInterferon-γMetastasisT lymphocytes

Identifiers

PMID39262976
PMCPMC11388388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.