ArticleASME letters in dynamic systems and control2024
A GENERATIVE APPROACH TO TESTING THE PERFORMANCE OF PHYSIOLOGICAL CONTROL ALGORITHMS.
Article in ASME letters in dynamic systems and control, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Comparative Assessment of In Vivo and In Silico Evaluation of Automated Fluid Resuscitation Controllers.Annals of biomedical engineering · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Background: Physiological closed-loop control algorithms play an important role in the development of autonomous medical care systems, a promising area of research that has the potential to deliver healthcare therapies meeting each patient's specific needs. Computational approaches can support the evaluation of physiological closed-loop control algorithms considering various sources of patient variability that they may be presented with. Method of Approach: In this paper, we present a generative approach to testing the performance of physiological closed-loop control algorithms. This approach exploits a generative physiological model (which consists of stochastic and dynamic components that represent diverse physiological behaviors across a patient population) to generate a select group of virtual subjects. By testing a physiological closed-loop control algorithm against this select group, the approach estimates the distribution of relevant performance metrics in the represented population. We illustrate the promise of this approach by applying it to a practical case study on testing a closed-loop fluid resuscitation control algorithm designed for hemodynamic management. Results: In this context, we show that the proposed approach can test the algorithm against virtual subjects equipped with a wide range of plausible physiological characteristics and behavior, and that the test results can be used to estimate the distribution of relevant performance metrics in the represented population. Conclusions: In sum, the generative testing approach may offer a practical, efficient solution for conducting pre-clinical tests on physiological closed-loop control algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.