Evidence map›Paper›PMID 39262794›Full record

ArticleiScience2024

Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells.

Jessica O'Sell, Vincenzo Cirulli, Stephanie Pardike, Marie Aare-Bentsen, Patima Sdek, Jasmine Anderson, Dale W Hailey, Mary C Regier, Sina A Gharib, Laura Crisa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jessica O'SellDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Vincenzo CirulliDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Stephanie PardikeDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Marie Aare-BentsenDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Patima SdekDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Jasmine AndersonDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Dale W HaileyDepartment of Laboratory Medicine and Pathology, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Mary C RegierInstitute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.
Sina A GharibComputational Medicine Core at Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA 98109, USA.
Laura CrisaDepartment of Medicine, Diabetes Institute, and Institute of Stem Cells and Regenerative Medicine, University of Washington, Seattle WA 98109, USA.

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Cell adhesion-dependent mechanisms of beta cell growth and homeostasisR01DK121275 · NIDDK · UNIVERSITY OF WASHINGTON · PI CIRULLI, VINCENZINO · 2020 to 2023
$2.5M
Myeloid cells in tissue growth and regenerationR01DK114693 · NIDDK · UNIVERSITY OF WASHINGTON · PI CRISA, LAURA · 2018 to 2021
$1.8M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK114693NIDDK NIH HHS R01 DK121275
6 · The paper itself

Abstract

Perinatal expansion of pancreatic β cells is critical to metabolic adaptation. Yet, mechanisms surveying the fidelity by which proliferative events generate functional β cell pools remain unknown. We have previously identified a CCR2

Indexed as

Cell biologyImmunologyPhysiologyTranscriptomics

Identifiers

PMID39262794
PMCPMC11388196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.